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Reviewed November 2011
What is the official name of the MATR3 gene?
The official name of this gene is “matrin 3.”
MATR3 is the gene's official symbol. The MATR3 gene is also known by other names, listed below.
Read more about gene names and symbols on the About page.
What is the normal function of the MATR3 gene?
The MATR3 gene provides instructions for making a protein called matrin 3, which is found in the nucleus of the cell as part of the nuclear matrix. The nuclear matrix is a network of proteins that provides structural support for the nucleus and aids in several important nuclear functions.
The function of the matrin 3 protein is unknown. This protein can attach to (bind) RNA, which is a chemical cousin of DNA. Some studies indicate that matrin 3 binds and stabilizes a type of RNA called messenger RNA (mRNA), which provides the genetic blueprint for proteins. Matrin 3 may also bind certain abnormal RNAs that could lead to nonfunctional or harmful proteins, thereby blocking the formation of such proteins. Other studies suggest that the matrin 3 protein may be involved in cell survival.
How are changes in the MATR3 gene related to health conditions?
Where is the MATR3 gene located?
Cytogenetic Location: 5q31.2
Molecular Location on chromosome 5: base pairs 139,273,751 to 139,331,676
The MATR3 gene is located on the long (q) arm of chromosome 5 at position 31.2.
More precisely, the MATR3 gene is located from base pair 139,273,751 to base pair 139,331,676 on chromosome 5.
See How do geneticists indicate the location of a gene? in the Handbook.
Where can I find additional information about MATR3?
You and your healthcare professional may find the following resources about MATR3 helpful.
You may also be interested in these resources, which are designed for genetics professionals and researchers.
What other names do people use for the MATR3 gene or gene products?
See How are genetic conditions and genes named? in the Handbook.
Where can I find general information about genes?
The Handbook provides basic information about genetics in clear language.
These links provide additional genetics resources that may be useful.
What glossary definitions help with understanding MATR3?
You may find definitions for these and many other terms in the Genetics Home Reference Glossary.
See also Understanding Medical Terminology.
References (7 links)
The resources on this site should not be used as a substitute for professional medical care or advice. Users seeking information about a personal genetic disease, syndrome, or condition should consult with a qualified healthcare professional. See How can I find a genetics professional in my area? in the Handbook.