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Reviewed April 2007
What is the official name of the MAT1A gene?
The official name of this gene is “methionine adenosyltransferase I, alpha.”
MAT1A is the gene's official symbol. The MAT1A gene is also known by other names, listed below.
Read more about gene names and symbols on the About page.
What is the normal function of the MAT1A gene?
The MAT1A gene provides instructions for producing the enzyme methionine adenosyltransferase. The enzyme is produced from the MAT1A gene in two forms, designated alpha and beta. The alpha form, called a homotetramer, is made up of four identical protein subunits. The beta form, called a homodimer, is made up of two of the same protein subunits. Both forms of the enzyme are found in the liver.
Both the alpha and beta forms of methionine adenosyltransferase help break down a protein building block (amino acid) called methionine. The enzyme starts the reaction that converts methionine to S-adenosylmethionine, also called AdoMet or SAMe. AdoMet is involved in transferring methyl groups, consisting of a carbon atom and three hydrogen atoms, to other compounds, a process called transmethylation. Transmethylation is important in many cellular processes. These include determining whether the instructions in a particular segment of DNA are carried out, regulating reactions involving proteins and lipids, and controlling the processing of chemicals that relay signals in the nervous system (neurotransmitters).
How are changes in the MAT1A gene related to health conditions?
Where is the MAT1A gene located?
Cytogenetic Location: 10q22
Molecular Location on chromosome 10: base pairs 80,271,820 to 80,289,979
(Homo sapiens Annotation Release 107, GRCh38.p2) (
The MAT1A gene is located on the long (q) arm of chromosome 10 at position 22.
More precisely, the MAT1A gene is located from base pair 80,271,820 to base pair 80,289,979 on chromosome 10.
See How do geneticists indicate the location of a gene? in the Handbook.
Where can I find additional information about MAT1A?
You and your healthcare professional may find the following resources about MAT1A helpful.
You may also be interested in these resources, which are designed for genetics professionals and researchers.
What other names do people use for the MAT1A gene or gene products?
See How are genetic conditions and genes named? in the Handbook.
Where can I find general information about genes?
The Handbook provides basic information about genetics in clear language.
These links provide additional genetics resources that may be useful.
What glossary definitions help with understanding MAT1A?
You may find definitions for these and many other terms in the Genetics Home Reference Glossary.
See also Understanding Medical Terminology.
References (7 links)
The resources on this site should not be used as a substitute for professional medical care or advice. Users seeking information about a personal genetic disease, syndrome, or condition should consult with a qualified healthcare professional. See How can I find a genetics professional in my area? in the Handbook.