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The information on this page was automatically extracted from online scientific databases.

What is the official name of the MAP2K5 gene?

The official name of this gene is “mitogen-activated protein kinase kinase 5.”

MAP2K5 is the gene's official symbol. The MAP2K5 gene is also known by other names, listed below.

Read more about gene names and symbols on the About page.

What is the normal function of the MAP2K5 gene?

From NCBI GeneThis link leads to a site outside Genetics Home Reference.:

The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase specifically interacts with and activates MAPK7/ERK5. This kinase itself can be phosphorylated and activated by MAP3K3/MEKK3, as well as by atypical protein kinase C isoforms (aPKCs). The signal cascade mediated by this kinase is involved in growth factor stimulated cell proliferation and muscle cell differentiation. Three alternatively spliced transcript variants of this gene encoding distinct isoforms have been described. [provided by RefSeq, May 2011]

From UniProt (MP2K5_HUMAN)This link leads to a site outside Genetics Home Reference.:

Acts as a scaffold for the formation of a ternary MAP3K2/MAP3K3-MAP3K5-MAPK7 signaling complex. Activation of this pathway appears to play a critical role in protecting cells from stress-induced apoptosis, neuronal survival and cardiac development and angiogenesis.

How are changes in the MAP2K5 gene related to health conditions?

Genetics Home Reference provides information about restless legs syndrome, which is associated with changes in the MAP2K5 gene.
OMIM.orgThis link leads to a site outside Genetics Home Reference., a catalog designed for genetics professionals and researchers, provides the following information about the MAP2K5 gene and its association with health conditions.

Where is the MAP2K5 gene located?

Cytogenetic Location: 15q23

Molecular Location on chromosome 15: base pairs 67,542,606 to 67,807,117

The MAP2K5 gene is located on the long (q) arm of chromosome 15 at position 23.

The MAP2K5 gene is located on the long (q) arm of chromosome 15 at position 23.

More precisely, the MAP2K5 gene is located from base pair 67,542,606 to base pair 67,807,117 on chromosome 15.

See How do geneticists indicate the location of a gene? in the Handbook.

Where can I find additional information about MAP2K5?

You may also be interested in these resources, which are designed for genetics professionals and researchers.

What other names do people use for the MAP2K5 gene or gene products?

  • HsT17454
  • MAPKK5
  • MEK5
  • PRKMK5

Where can I find general information about genes?

The Handbook provides basic information about genetics in clear language.

These links provide additional genetics resources that may be useful.

What glossary definitions help with understanding MAP2K5?

angiogenesis ; apoptosis ; atypical ; cardiac ; cell ; cell proliferation ; differentiation ; gene ; growth factor ; isoforms ; kinase ; muscle cell ; proliferation ; protein ; specificity ; stress ; transcript

You may find definitions for these and many other terms in the Genetics Home Reference Glossary.

See also Understanding Medical Terminology.


The resources on this site should not be used as a substitute for professional medical care or advice. Users seeking information about a personal genetic disease, syndrome, or condition should consult with a qualified healthcare professional. See How can I find a genetics professional in my area? in the Handbook.

Published: November 23, 2015