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Reviewed May 2012
What is the official name of the MAP2K2 gene?
The official name of this gene is “mitogen-activated protein kinase kinase 2.”
MAP2K2 is the gene's official symbol. The MAP2K2 gene is also known by other names, listed below.
Read more about gene names and symbols on the About page.
What is the normal function of the MAP2K2 gene?
The MAP2K2 gene provides instructions for making a protein known as MEK2 protein kinase. This protein is part of a signaling pathway called the RAS/MAPK pathway, which transmits chemical signals from outside the cell to the cell's nucleus. RAS/MAPK signaling helps control the growth and division (proliferation) of cells, the process by which cells mature to carry out specific functions (differentiation), cell movement, and the self-destruction of cells (apoptosis).
The MAP2K2 gene is very similar to a gene called MAP2K1, which provides instructions for making a protein known as MEK1 protein kinase. Like MEK2 protein kinase, this protein functions as part of the RAS/MAPK signaling pathway. Together, the MEK1 and MEK2 protein kinases appear to be essential for normal development before birth and for survival after birth.
How are changes in the MAP2K2 gene related to health conditions?
Where is the MAP2K2 gene located?
Cytogenetic Location: 19p13.3
Molecular Location on chromosome 19: base pairs 4,090,321 to 4,124,184
(Homo sapiens Annotation Release 107, GRCh38.p2) (
The MAP2K2 gene is located on the short (p) arm of chromosome 19 at position 13.3.
More precisely, the MAP2K2 gene is located from base pair 4,090,321 to base pair 4,124,184 on chromosome 19.
See How do geneticists indicate the location of a gene? in the Handbook.
Where can I find additional information about MAP2K2?
You and your healthcare professional may find the following resources about MAP2K2 helpful.
You may also be interested in these resources, which are designed for genetics professionals and researchers.
What other names do people use for the MAP2K2 gene or gene products?
See How are genetic conditions and genes named? in the Handbook.
Where can I find general information about genes?
The Handbook provides basic information about genetics in clear language.
These links provide additional genetics resources that may be useful.
What glossary definitions help with understanding MAP2K2?
You may find definitions for these and many other terms in the Genetics Home Reference Glossary.
See also Understanding Medical Terminology.
References (6 links)
The resources on this site should not be used as a substitute for professional medical care or advice. Users seeking information about a personal genetic disease, syndrome, or condition should consult with a qualified healthcare professional. See How can I find a genetics professional in my area? in the Handbook.