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MAOA

MAOA

The information on this page was automatically extracted from online scientific databases.

What is the official name of the MAOA gene?

The official name of this gene is “monoamine oxidase A.”

MAOA is the gene's official symbol. The MAOA gene is also known by other names, listed below.

Read more about gene names and symbols on the About page.

What is the normal function of the MAOA gene?

From NCBI GeneThis link leads to a site outside Genetics Home Reference.:

This gene is one of two neighboring gene family members that encode mitochondrial enzymes which catalyze the oxidative deamination of amines, such as dopamine, norepinephrine, and serotonin. Mutation of this gene results in Brunner syndrome. This gene has also been associated with a variety of other psychiatric disorders, including antisocial behavior. Alternatively spliced transcript variants encoding multiple isoforms have been observed. [provided by RefSeq, Jul 2012]

From UniProtThis link leads to a site outside Genetics Home Reference.:

Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. MAOA preferentially oxidizes biogenic amines such as 5-hydroxytryptamine (5-HT), norepinephrine and epinephrine.

How are changes in the MAOA gene related to health conditions?

UniProtThis link leads to a site outside Genetics Home Reference. provides the following information about the MAOA gene's known or predicted involvement in human disease.

Brunner syndrome (BRUNS): A form of X-linked non-dysmorphic mild mental retardation. Male patients are affected by borderline mental retardation and exhibit abnormal behavior, including disturbed regulation of impulsive aggression. Obligate female carriers have normal intelligence and behavior.[1]This link leads to a site outside Genetics Home Reference. The disease is caused by mutations affecting the gene represented in this entry.

NCBI GeneThis link leads to a site outside Genetics Home Reference. lists the following diseases or traits (phenotypes) known or believed to be associated with changes in the MAOA gene.
  • Monoamine oxidase A deficiency[1]This link leads to a site outside Genetics Home Reference.
UniProt and NCBI Gene cite these articles in OMIM, a catalog designed for genetics professionals and researchers that provides detailed information about genetic conditions and genes.
 Article
Number
Main Topic
[1]

Where is the MAOA gene located?

Cytogenetic Location: Xp11.3

Molecular Location on the X chromosome: base pairs 43,654,906 to 43,746,823

The MAOA gene is located on the short (p) arm of the X chromosome at position 11.3.

The MAOA gene is located on the short (p) arm of the X chromosome at position 11.3.

More precisely, the MAOA gene is located from base pair 43,654,906 to base pair 43,746,823 on the X chromosome.

See How do geneticists indicate the location of a gene? in the Handbook.

Where can I find additional information about MAOA?

You and your healthcare professional may find the following resources about MAOA helpful.

You may also be interested in these resources, which are designed for genetics professionals and researchers.

What other names do people use for the MAOA gene or gene products?

  • MAO-A

Where can I find general information about genes?

The Handbook provides basic information about genetics in clear language.

These links provide additional genetics resources that may be useful.

What glossary definitions help with understanding MAOA?

central nervous system ; deficiency ; dopamine ; gene ; HT ; isoforms ; mental retardation ; metabolism ; mutation ; nervous system ; oxidase ; peripheral ; syndrome ; transcript ; xenobiotic

You may find definitions for these and many other terms in the Genetics Home Reference Glossary.

See also Understanding Medical Terminology.

 

The resources on this site should not be used as a substitute for professional medical care or advice. Users seeking information about a personal genetic disease, syndrome, or condition should consult with a qualified healthcare professional. See How can I find a genetics professional in my area? in the Handbook.

 
Published: October 27, 2014