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Reviewed June 2014
What is the official name of the MAGT1 gene?
The official name of this gene is “magnesium transporter 1.”
MAGT1 is the gene's official symbol. The MAGT1 gene is also known by other names, listed below.
Read more about gene names and symbols on the About page.
What is the normal function of the MAGT1 gene?
The MAGT1 gene provides instructions for making a protein called a magnesium transporter, which moves charged atoms (ions) of magnesium (Mg2+) into certain immune system cells called T cells. T cells recognize foreign invaders, such as viruses, bacteria, and fungi, and are then turned on (activated) to attack these invaders in order to prevent infection and illness. Specifically, the magnesium transporter produced from the MAGT1 gene is active in CD8+ T cells, which are especially important in controlling viral infections such as the Epstein-Barr virus (EBV). These cells normally take in magnesium when they detect a foreign invader, and the magnesium is involved in activating the T cell's response.
Researchers suggest that magnesium transport may also be involved in the production of another type of T cell called helper T cells (CD4+ T cells) in a gland called the thymus. CD4+ T cells direct and assist the functions of the immune system by influencing the activities of other immune system cells.
How are changes in the MAGT1 gene related to health conditions?
Where is the MAGT1 gene located?
Cytogenetic Location: Xq21.1
Molecular Location on the X chromosome: base pairs 77,826,364 to 77,895,568
The MAGT1 gene is located on the long (q) arm of the X chromosome at position 21.1.
More precisely, the MAGT1 gene is located from base pair 77,826,364 to base pair 77,895,568 on the X chromosome.
See How do geneticists indicate the location of a gene? in the Handbook.
Where can I find additional information about MAGT1?
You and your healthcare professional may find the following resources about MAGT1 helpful.
You may also be interested in these resources, which are designed for genetics professionals and researchers.
What other names do people use for the MAGT1 gene or gene products?
See How are genetic conditions and genes named? in the Handbook.
Where can I find general information about genes?
The Handbook provides basic information about genetics in clear language.
These links provide additional genetics resources that may be useful.
What glossary definitions help with understanding MAGT1?
You may find definitions for these and many other terms in the Genetics Home Reference Glossary.
See also Understanding Medical Terminology.
References (8 links)
The resources on this site should not be used as a substitute for professional medical care or advice. Users seeking information about a personal genetic disease, syndrome, or condition should consult with a qualified healthcare professional. See How can I find a genetics professional in my area? in the Handbook.