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Reviewed June 2014

What is the official name of the MAGT1 gene?

The official name of this gene is “magnesium transporter 1.”

MAGT1 is the gene's official symbol. The MAGT1 gene is also known by other names, listed below.

Read more about gene names and symbols on the About page.

What is the normal function of the MAGT1 gene?

The MAGT1 gene provides instructions for making a protein called a magnesium transporter, which moves charged atoms (ions) of magnesium (Mg2+) into certain immune system cells called T cells. T cells recognize foreign invaders, such as viruses, bacteria, and fungi, and are then turned on (activated) to attack these invaders in order to prevent infection and illness. Specifically, the magnesium transporter produced from the MAGT1 gene is active in CD8+ T cells, which are especially important in controlling viral infections such as the Epstein-Barr virus (EBV). These cells normally take in magnesium when they detect a foreign invader, and the magnesium is involved in activating the T cell's response.

Researchers suggest that magnesium transport may also be involved in the production of another type of T cell called helper T cells (CD4+ T cells) in a gland called the thymus. CD4+ T cells direct and assist the functions of the immune system by influencing the activities of other immune system cells.

How are changes in the MAGT1 gene related to health conditions?

X-linked immunodeficiency with magnesium defect, Epstein-Barr virus infection, and neoplasia - caused by mutations in the MAGT1 gene

At least five MAGT1 gene mutations that cause X-linked immunodeficiency with magnesium defect, Epstein-Barr virus infection, and neoplasia (typically known by the acronym XMEN) have been identified. XMEN is a disorder that affects the immune system in males. It involves chronic EBV infection and an increased risk of a cancer of immune system cells called lymphoma. The word "neoplasia" in the condition name refers to these lymphomas; neoplasia is a general term meaning abnormal growths of tissue.

MAGT1 gene mutations impair the magnesium transporter's function, reducing the amount of magnesium that gets into T cells. This magnesium deficiency prevents the efficient activation of the T cells to target EBV and other infections. Uncontrolled EBV infection increases the likelihood of developing lymphoma. Impaired production of CD4+ T cells resulting from abnormal magnesium transport likely accounts for the deficiency of this type of T cell in individuals with XMEN, contributing to the decreased ability to prevent infection and illness.

Where is the MAGT1 gene located?

Cytogenetic Location: Xq21.1

Molecular Location on the X chromosome: base pairs 77,826,364 to 77,895,568

(Homo sapiens Annotation Release 107, GRCh38.p2) (NCBIThis link leads to a site outside Genetics Home Reference.)

The MAGT1 gene is located on the long (q) arm of the X chromosome at position 21.1.

The MAGT1 gene is located on the long (q) arm of the X chromosome at position 21.1.

More precisely, the MAGT1 gene is located from base pair 77,826,364 to base pair 77,895,568 on the X chromosome.

See How do geneticists indicate the location of a gene? in the Handbook.

Where can I find additional information about MAGT1?

You and your healthcare professional may find the following resources about MAGT1 helpful.

You may also be interested in these resources, which are designed for genetics professionals and researchers.

What other names do people use for the MAGT1 gene or gene products?

  • bA217H1.1
  • DKFZp564K142
  • IAP
  • implantation-associated protein
  • magnesium transporter protein 1
  • MRX95
  • oligosaccharyltransferase 3 homolog B
  • OST3B
  • PRO0756
  • XMEN

Where can I find general information about genes?

The Handbook provides basic information about genetics in clear language.

These links provide additional genetics resources that may be useful.

What glossary definitions help with understanding MAGT1?

bacteria ; cancer ; cell ; chronic ; deficiency ; gene ; immune system ; immunodeficiency ; infection ; ions ; lymphoma ; neoplasia ; protein ; thymus ; tissue ; virus

You may find definitions for these and many other terms in the Genetics Home Reference Glossary.

See also Understanding Medical Terminology.

References (8 links)


The resources on this site should not be used as a substitute for professional medical care or advice. Users seeking information about a personal genetic disease, syndrome, or condition should consult with a qualified healthcare professional. See How can I find a genetics professional in my area? in the Handbook.

Reviewed: June 2014
Published: February 8, 2016