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Reviewed February 2008
What is the official name of the LYST gene?
The official name of this gene is “lysosomal trafficking regulator.”
LYST is the gene's official symbol. The LYST gene is also known by other names, listed below.
Read more about gene names and symbols on the About page.
What is the normal function of the LYST gene?
The LYST gene (also known as CHS1) provides instructions for making a protein known as the lysosomal trafficking regulator. Researchers believe that this protein plays a role in the transport (trafficking) of materials into structures called lysosomes. Lysosomes act as recycling centers within cells. They use digestive enzymes to break down toxic substances, digest bacteria that invade the cell, and recycle worn-out cell components. Although the lysosomal trafficking regulator protein is involved in the normal function of lysosomes, its exact role is unknown. Studies suggest that this protein may help determine the size of lysosomes and regulate their movement within cells.
Does the LYST gene share characteristics with other genes?
The LYST gene belongs to a family of genes called WDR (WD repeat domain containing).
A gene family is a group of genes that share important characteristics. Classifying individual genes into families helps researchers describe how genes are related to each other. For more information, see What are gene families? in the Handbook.
How are changes in the LYST gene related to health conditions?
Where is the LYST gene located?
Cytogenetic Location: 1q42.1-q42.2
Molecular Location on chromosome 1: base pairs 235,661,031 to 235,883,708
(Homo sapiens Annotation Release 107, GRCh38.p2) (
The LYST gene is located on the long (q) arm of chromosome 1 between positions 42.1 and 42.2.
More precisely, the LYST gene is located from base pair 235,661,031 to base pair 235,883,708 on chromosome 1.
See How do geneticists indicate the location of a gene? in the Handbook.
Where can I find additional information about LYST?
You and your healthcare professional may find the following resources about LYST helpful.
You may also be interested in these resources, which are designed for genetics professionals and researchers.
What other names do people use for the LYST gene or gene products?
See How are genetic conditions and genes named? in the Handbook.
Where can I find general information about genes?
The Handbook provides basic information about genetics in clear language.
These links provide additional genetics resources that may be useful.
What glossary definitions help with understanding LYST?
albinism ; amino acid ; bacteria ; cell ; digestive ; gene ; immune system ; lysosome ; melanin ; melanocytes ; neurological ; pigment ; pigmentation ; platelets ; protein ; syndrome ; toxic ; vesicle
You may find definitions for these and many other terms in the Genetics Home Reference Glossary.
See also Understanding Medical Terminology.
References (8 links)
The resources on this site should not be used as a substitute for professional medical care or advice. Users seeking information about a personal genetic disease, syndrome, or condition should consult with a qualified healthcare professional. See How can I find a genetics professional in my area? in the Handbook.