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Reviewed January 2013
What is the official name of the LRP5 gene?
The official name of this gene is “LDL receptor related protein 5.”
LRP5 is the gene's official symbol. The LRP5 gene is also known by other names, listed below.
Read more about gene names and symbols on the About page.
What is the normal function of the LRP5 gene?
The LRP5 gene provides instructions for making a protein that is embedded in the outer membrane of many types of cells. It is known as a co-receptor because it works with another receptor protein, frizzled-4 (produced from the FZD4 gene), to transmit chemical signals from outside the cell to the cell's nucleus. Frizzled-4 and the LRP5 protein participate in the Wnt signaling pathway, a series of steps that affect the way cells and tissues develop. Wnt signaling is important for cell division (proliferation), attachment of cells to one another (adhesion), cell movement (migration), and many other cellular activities.
The LRP5 protein plays an important role in the development and maintenance of several tissues. During early development, it helps guide the specialization of cells in the retina, which is the light-sensitive tissue at the back of the eye. The LRP5 protein is also involved in establishing a blood supply to the retina and the inner ear. Additionally, this protein helps regulate bone mineral density, which is a measure of the amount of calcium and other minerals in bones. The minerals give the bones strength, making them less likely to break.
How are changes in the LRP5 gene related to health conditions?
Where is the LRP5 gene located?
Cytogenetic Location: 11q13.4
Molecular Location on chromosome 11: base pairs 68,298,866 to 68,449,275
The LRP5 gene is located on the long (q) arm of chromosome 11 at position 13.4.
More precisely, the LRP5 gene is located from base pair 68,298,866 to base pair 68,449,275 on chromosome 11.
See How do geneticists indicate the location of a gene? in the Handbook.
Where can I find additional information about LRP5?
You and your healthcare professional may find the following resources about LRP5 helpful.
You may also be interested in these resources, which are designed for genetics professionals and researchers.
What other names do people use for the LRP5 gene or gene products?
See How are genetic conditions and genes named? in the Handbook.
Where can I find general information about genes?
The Handbook provides basic information about genetics in clear language.
These links provide additional genetics resources that may be useful.
What glossary definitions help with understanding LRP5?
acids ; autosomal ; autosomal dominant ; bone formation ; bone mineral density ; calcium ; cell ; cell division ; familial ; gene ; hyperostosis ; juvenile ; LDL ; lipoprotein ; mineral ; nucleus ; osteoporosis ; proliferation ; protein ; pseudoglioma ; receptor ; retina ; syndrome ; tissue
You may find definitions for these and many other terms in the Genetics Home Reference Glossary.
See also Understanding Medical Terminology.
References (16 links)
The resources on this site should not be used as a substitute for professional medical care or advice. Users seeking information about a personal genetic disease, syndrome, or condition should consult with a qualified healthcare professional. See How can I find a genetics professional in my area? in the Handbook.