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Reviewed April 2013
What is the official name of the LRP2 gene?
The official name of this gene is “LDL receptor related protein 2.”
LRP2 is the gene's official symbol. The LRP2 gene is also known by other names, listed below.
Read more about gene names and symbols on the About page.
What is the normal function of the LRP2 gene?
The LRP2 gene provides instructions for making a protein called megalin, which functions as a receptor. Receptor proteins have specific sites into which certain other proteins, called ligands, fit like keys into locks. Together, ligands and their receptors trigger signals that affect cell development and function. Megalin has many ligands involved in various body processes, including the absorption of vitamins A and D, immune functioning, stress response, and the transport of fats in the bloodstream.
Megalin is embedded in the membrane of cells that line the surfaces and cavities of the body (epithelial cells). The receptor helps move its ligands from the cell surface into the cell (endocytosis), and is also involved in transporting the ligands of a related receptor called cubulin. Megalin is active in the development and function of many parts of the body, including the brain and spinal cord (central nervous system), eyes, ears, lungs, intestine, reproductive system, and the small tubes in the kidneys where urine is formed (renal tubules).
How are changes in the LRP2 gene related to health conditions?
Genetics Home Reference provides information about prostate cancer, which is also associated with changes in the LRP2 gene.
Where is the LRP2 gene located?
Cytogenetic Location: 2q31.1
Molecular Location on chromosome 2: base pairs 169,127,109 to 169,362,613
(Homo sapiens Annotation Release 107, GRCh38.p2) (
The LRP2 gene is located on the long (q) arm of chromosome 2 at position 31.1.
More precisely, the LRP2 gene is located from base pair 169,127,109 to base pair 169,362,613 on chromosome 2.
See How do geneticists indicate the location of a gene? in the Handbook.
Where can I find additional information about LRP2?
You and your healthcare professional may find the following resources about LRP2 helpful.
You may also be interested in these resources, which are designed for genetics professionals and researchers.
What other names do people use for the LRP2 gene or gene products?
See How are genetic conditions and genes named? in the Handbook.
Where can I find general information about genes?
The Handbook provides basic information about genetics in clear language.
These links provide additional genetics resources that may be useful.
What glossary definitions help with understanding LRP2?
androgens ; calcium ; cancer ; cardiovascular ; cell ; central nervous system ; cholesterol ; endocytosis ; epithelial ; gene ; intestine ; LDL ; lipoprotein ; low-density lipoproteins ; nephritis ; nervous system ; progression ; prostate ; protein ; receptor ; renal ; stress ; syndrome ; tumor ; vitamins
You may find definitions for these and many other terms in the Genetics Home Reference Glossary.
See also Understanding Medical Terminology.
References (9 links)
The resources on this site should not be used as a substitute for professional medical care or advice. Users seeking information about a personal genetic disease, syndrome, or condition should consult with a qualified healthcare professional. See How can I find a genetics professional in my area? in the Handbook.