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Reviewed February 2015
What is the official name of the LPL gene?
The official name of this gene is “lipoprotein lipase.”
LPL is the gene's official symbol. The LPL gene is also known by other names, listed below.
Read more about gene names and symbols on the About page.
What is the normal function of the LPL gene?
The LPL gene provides instructions for making an enzyme called lipoprotein lipase. This enzyme is found primarily on the surface of cells that line tiny blood vessels (capillaries) within muscles and in fatty (adipose) tissue. Lipoprotein lipase plays a critical role in breaking down fat in the form of triglycerides, which are carried from various organs to the blood by molecules called lipoproteins.
Lipoprotein lipase breaks down triglycerides carried by two different types of lipoproteins, which bring fat to the bloodstream from different organs. Fat from the intestine, which is taken in from the diet, is transported to the bloodstream by lipoproteins called chylomicrons. Another type of lipoprotein called very low density lipoprotein (VLDL) carries triglycerides from the liver to the bloodstream. When lipoprotein lipase breaks down triglycerides, the fat molecules are used by the body as energy or stored in fatty tissue for later use.
How are changes in the LPL gene related to health conditions?
Where is the LPL gene located?
Cytogenetic Location: 8p22
Molecular Location on chromosome 8: base pairs 19,939,070 to 19,967,258
The LPL gene is located on the short (p) arm of chromosome 8 at position 22.
More precisely, the LPL gene is located from base pair 19,939,070 to base pair 19,967,258 on chromosome 8.
See How do geneticists indicate the location of a gene? in the Handbook.
Where can I find additional information about LPL?
You and your healthcare professional may find the following resources about LPL helpful.
You may also be interested in these resources, which are designed for genetics professionals and researchers.
What other names do people use for the LPL gene or gene products?
See How are genetic conditions and genes named? in the Handbook.
Where can I find general information about genes?
The Handbook provides basic information about genetics in clear language.
These links provide additional genetics resources that may be useful.
What glossary definitions help with understanding LPL?
acids ; amino acid ; arteries ; artery ; atherosclerosis ; breakdown ; capillaries ; chylomicrons ; deficiency ; enzyme ; familial ; fatty acids ; fatty tissue ; gene ; glutamic acid ; glycine ; heart attack ; hepatosplenomegaly ; inflammation ; intestine ; lipase ; lipid ; lipoprotein ; metabolism ; mutation ; oxidation ; pancreas ; pancreatitis ; protein ; tissue ; triacylglycerol ; triglycerides ; very low density lipoprotein ; VLDL
You may find definitions for these and many other terms in the Genetics Home Reference Glossary.
See also Understanding Medical Terminology.
References (8 links)
The resources on this site should not be used as a substitute for professional medical care or advice. Users seeking information about a personal genetic disease, syndrome, or condition should consult with a qualified healthcare professional. See How can I find a genetics professional in my area? in the Handbook.