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Reviewed January 2008
What is the official name of the LPL gene?
The official name of this gene is “lipoprotein lipase.”
LPL is the gene's official symbol. The LPL gene is also known by other names, listed below.
Read more about gene names and symbols on the About page.
What is the normal function of the LPL gene?
The LPL gene provides instructions for making an enzyme called lipoprotein lipase. This enzyme is made primarily in fatty (adipose) tissue and in muscle. It plays a critical role in transporting fats and breaking down fat-carrying molecules called lipoproteins.
Lipoprotein lipase removes fatty substances from two types of lipoproteins: chylomicrons and very low density lipoproteins (VLDLs). After a meal, chylomicrons are formed to carry fat from the intestine into the bloodstream. VLDLs are molecules that circulate in the blood, carrying fat and cholesterol from the liver to other tissues throughout the body. Lipoprotein lipase works with another enzyme (apolipoprotein C-II) to remove fats from chylomicrons and VLDLs. The breakdown of these particles releases fat molecules for energy use or for storage in adipose tissue.
How are changes in the LPL gene related to health conditions?
Where is the LPL gene located?
Cytogenetic Location: 8p22
Molecular Location on chromosome 8: base pairs 19,939,070 to 19,967,258
The LPL gene is located on the short (p) arm of chromosome 8 at position 22.
More precisely, the LPL gene is located from base pair 19,939,070 to base pair 19,967,258 on chromosome 8.
See How do geneticists indicate the location of a gene? in the Handbook.
Where can I find additional information about LPL?
You and your healthcare professional may find the following resources about LPL helpful.
You may also be interested in these resources, which are designed for genetics professionals and researchers.
What other names do people use for the LPL gene or gene products?
See How are genetic conditions and genes named? in the Handbook.
Where can I find general information about genes?
The Handbook provides basic information about genetics in clear language.
These links provide additional genetics resources that may be useful.
What glossary definitions help with understanding LPL?
adipose tissue ; amino acid ; apolipoprotein ; arteries ; atherosclerosis ; cachexia ; cholesterol ; chronic ; chylomicrons ; deficiency ; diabetes ; enzyme ; familial ; gene ; glutamic acid ; glycine ; heart attack ; intestine ; lipase ; lipid ; lipoprotein ; metabolism ; mutation ; protein ; tissue ; triacylglycerol ; wasting
You may find definitions for these and many other terms in the Genetics Home Reference Glossary.
See also Understanding Medical Terminology.
References (7 links)
The resources on this site should not be used as a substitute for professional medical care or advice. Users seeking information about a personal genetic disease, syndrome, or condition should consult with a qualified healthcare professional. See How can I find a genetics professional in my area? in the Handbook.