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Reviewed April 2013
What is the official name of the LPAR6 gene?
The official name of this gene is “lysophosphatidic acid receptor 6.”
LPAR6 is the gene's official symbol. The LPAR6 gene is also known by other names, listed below.
Read more about gene names and symbols on the About page.
What is the normal function of the LPAR6 gene?
The LPAR6 gene provides instructions for making a protein called lysophosphatidic acid receptor 6 (LPA6). This protein functions as a receptor. Receptor proteins have particular sites into which certain other proteins, called ligands, fit like keys into locks. A specific fat called lysophosphatidic acid (LPA) is the ligand for the LPA6 protein. LPA can attach to many receptors, but LPA6 is the only LPA receptor found in hair follicles. Hair follicles are specialized structures in the skin where hair growth occurs. As the cells in the hair follicle divide, the hair strand (shaft) is pushed upward and extends beyond the skin, causing the hair to grow. The LPA6 protein is also found in the outermost layer of skin (the epidermis). Attachment of LPA to LPA6 helps regulate the growth and division (proliferation) and maturation (differentiation) of cells in the hair follicle.
Does the LPAR6 gene share characteristics with other genes?
The LPAR6 gene belongs to a family of genes called GPCR (G protein-coupled receptors).
A gene family is a group of genes that share important characteristics. Classifying individual genes into families helps researchers describe how genes are related to each other. For more information, see What are gene families? in the Handbook.
How are changes in the LPAR6 gene related to health conditions?
Where is the LPAR6 gene located?
Cytogenetic Location: 13q14
Molecular Location on chromosome 13: base pairs 48,411,044 to 48,444,703
The LPAR6 gene is located on the long (q) arm of chromosome 13 at position 14.
More precisely, the LPAR6 gene is located from base pair 48,411,044 to base pair 48,444,703 on chromosome 13.
See How do geneticists indicate the location of a gene? in the Handbook.
Where can I find additional information about LPAR6?
You and your healthcare professional may find the following resources about LPAR6 helpful.
You may also be interested in these resources, which are designed for genetics professionals and researchers.
What other names do people use for the LPAR6 gene or gene products?
See How are genetic conditions and genes named? in the Handbook.
Where can I find general information about genes?
The Handbook provides basic information about genetics in clear language.
These links provide additional genetics resources that may be useful.
What glossary definitions help with understanding LPAR6?
autosomal ; autosomal recessive ; cell ; cell proliferation ; differentiation ; epidermis ; gene ; hair follicle ; hypotrichosis ; intron ; ligand ; proliferation ; protein ; receptor ; recessive ; spectrum
You may find definitions for these and many other terms in the Genetics Home Reference Glossary.
See also Understanding Medical Terminology.
References (8 links)
The resources on this site should not be used as a substitute for professional medical care or advice. Users seeking information about a personal genetic disease, syndrome, or condition should consult with a qualified healthcare professional. See How can I find a genetics professional in my area? in the Handbook.