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LIPI

LIPI

The information on this page was automatically extracted from online scientific databases.

What is the official name of the LIPI gene?

The official name of this gene is “lipase, member I.”

LIPI is the gene's official symbol. The LIPI gene is also known by other names, listed below.

Read more about gene names and symbols on the About page.

What is the normal function of the LIPI gene?

From NCBI GeneThis link leads to a site outside Genetics Home Reference.:

The protein encoded by this gene is a phospholipase that hydrolyzes phosphatidic acid to produce lysophosphatidic acid. The encoded protein, which can be inhibited by sodium vanadate, may be found exclusively in sperm. Defects in this gene are a cause of susceptibility to familial hypertrigliceridemia. [provided by RefSeq, Jun 2010]

From UniProtThis link leads to a site outside Genetics Home Reference.:

Hydrolyzes specifically phosphatidic acid (PA) to produce 2-acyl lysophosphatidic acid (LPA; a potent bioactive lipid mediator) and fatty acid. Does not hydrolyze other phospholipids, like phosphatidylserine (PS), phosphatidylcholine (PC) and phosphatidylethanolamine (PE) or triacylglycerol (TG).

How are changes in the LIPI gene related to health conditions?

UniProtThis link leads to a site outside Genetics Home Reference. provides the following information about the LIPI gene's known or predicted involvement in human disease.

Hypertriglyceridemia, familial (FHTR): A common inherited disorder in which the concentration of very low density lipoprotein (VLDL) is elevated in the plasma. This leads to increased risk of heart disease, obesity, and pancreatitis.[1]This link leads to a site outside Genetics Home Reference. Disease susceptibility is associated with variations affecting the gene represented in this entry.

NCBI GeneThis link leads to a site outside Genetics Home Reference. lists the following diseases or traits (phenotypes) known or believed to be associated with changes in the LIPI gene.
  • Familial hypertriglyceridemia[1]This link leads to a site outside Genetics Home Reference.
UniProt and NCBI Gene cite these articles in OMIM, a catalog designed for genetics professionals and researchers that provides detailed information about genetic conditions and genes.
 Article
Number
Main Topic
[1]

Where is the LIPI gene located?

Cytogenetic Location: 21q11.2

Molecular Location on chromosome 21: base pairs 14,108,462 to 14,211,039

The LIPI gene is located on the long (q) arm of chromosome 21 at position 11.2.

The LIPI gene is located on the long (q) arm of chromosome 21 at position 11.2.

More precisely, the LIPI gene is located from base pair 14,108,462 to base pair 14,211,039 on chromosome 21.

See How do geneticists indicate the location of a gene? in the Handbook.

Where can I find additional information about LIPI?

You and your healthcare professional may find the following resources about LIPI helpful.

You may also be interested in these resources, which are designed for genetics professionals and researchers.

What other names do people use for the LIPI gene or gene products?

  • CT17
  • LPDL
  • PLA1C
  • PRED5

Where can I find general information about genes?

The Handbook provides basic information about genetics in clear language.

These links provide additional genetics resources that may be useful.

What glossary definitions help with understanding LIPI?

familial ; gene ; hypertriglyceridemia ; inherited ; lipid ; lipoprotein ; pancreatitis ; phospholipids ; plasma ; protein ; sodium ; sperm ; susceptibility ; triacylglycerol ; very low density lipoprotein ; VLDL

You may find definitions for these and many other terms in the Genetics Home Reference Glossary.

See also Understanding Medical Terminology.

 

The resources on this site should not be used as a substitute for professional medical care or advice. Users seeking information about a personal genetic disease, syndrome, or condition should consult with a qualified healthcare professional. See How can I find a genetics professional in my area? in the Handbook.

 
Published: July 21, 2014