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Reviewed April 2013
What is the official name of the LIPH gene?
The official name of this gene is “lipase H.”
LIPH is the gene's official symbol. The LIPH gene is also known by other names, listed below.
Read more about gene names and symbols on the About page.
What is the normal function of the LIPH gene?
The LIPH gene provides instructions for making an enzyme called lipase H. This enzyme is found in many cells and tissues, where it breaks down the molecule phosphatidic acid into lysophosphatidic acid (LPA) and free fatty acid. LPA is a ligand, which means that it attaches (binds) to certain proteins called receptors. A ligand and its receptor fit together like a key in a lock. LPA has multiple receptors and is involved in many cellular functions, such as cell growth and division (proliferation), cell movement (migration), and the self-destruction of cells (apoptosis).
One of LPA's receptors, the LPA6 protein, regulates the proliferation and maturation (differentiation) of cells within hair follicles, which are specialized structures in the skin where hair growth occurs. These cell processes are important for the normal development of hair follicles and for hair growth; as the cells in the hair follicle divide, the hair strand (shaft) is pushed upward and extends beyond the skin, causing the hair to grow. Lipase H is also found in the outermost layer of skin (the epidermis) and glands in the skin that produce a substance that protects the skin and hair (sebaceous glands).
How are changes in the LIPH gene related to health conditions?
Where is the LIPH gene located?
Cytogenetic Location: 3q27
Molecular Location on chromosome 3: base pairs 185,506,866 to 185,552,655
(Homo sapiens Annotation Release 107, GRCh38.p2) (
The LIPH gene is located on the long (q) arm of chromosome 3 at position 27.
More precisely, the LIPH gene is located from base pair 185,506,866 to base pair 185,552,655 on chromosome 3.
See How do geneticists indicate the location of a gene? in the Handbook.
Where can I find additional information about LIPH?
You and your healthcare professional may find the following resources about LIPH helpful.
You may also be interested in these resources, which are designed for genetics professionals and researchers.
What other names do people use for the LIPH gene or gene products?
See How are genetic conditions and genes named? in the Handbook.
Where can I find general information about genes?
The Handbook provides basic information about genetics in clear language.
These links provide additional genetics resources that may be useful.
What glossary definitions help with understanding LIPH?
apoptosis ; autosomal ; autosomal recessive ; cell ; differentiation ; enzyme ; epidermis ; gene ; hair follicle ; hypotrichosis ; ligand ; lipase ; molecule ; proliferation ; protein ; receptor ; recessive ; spectrum
You may find definitions for these and many other terms in the Genetics Home Reference Glossary.
See also Understanding Medical Terminology.
References (9 links)
The resources on this site should not be used as a substitute for professional medical care or advice. Users seeking information about a personal genetic disease, syndrome, or condition should consult with a qualified healthcare professional. See How can I find a genetics professional in my area? in the Handbook.