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Reviewed October 2007
What is the official name of the LIPA gene?
The official name of this gene is “lipase A, lysosomal acid, cholesterol esterase.”
LIPA is the gene's official symbol. The LIPA gene is also known by other names, listed below.
Read more about gene names and symbols on the About page.
What is the normal function of the LIPA gene?
The LIPA gene provides instructions for making an enzyme called lysosomal acid lipase. This enzyme is found in the lysosomes (compartments that digest and recycle materials in the cell), where it breaks down fats (lipids) such as cholesteryl esters and triglycerides.
In the body, cholesterol works with high-density lipoproteins (HDL), often referred to as "good cholesterol." High-density lipoproteins carry cholesterol from the body's tissues to the liver for removal. When the cholesterol is attached to a fatty acid it is a cholesteryl ester. Normally, the cholesteryl esters are broken down by lysosomal acid lipase into cholesterol and a fatty acid and then excreted or used by the body as nutrients.
How are changes in the LIPA gene related to health conditions?
Where is the LIPA gene located?
Cytogenetic Location: 10q23.2-q23.3
Molecular Location on chromosome 10: base pairs 89,213,568 to 89,252,038
The LIPA gene is located on the long (q) arm of chromosome 10 between positions 23.2 and 23.3.
More precisely, the LIPA gene is located from base pair 89,213,568 to base pair 89,252,038 on chromosome 10.
See How do geneticists indicate the location of a gene? in the Handbook.
Where can I find additional information about LIPA?
You and your healthcare professional may find the following resources about LIPA helpful.
You may also be interested in these resources, which are designed for genetics professionals and researchers.
What other names do people use for the LIPA gene or gene products?
See How are genetic conditions and genes named? in the Handbook.
Where can I find general information about genes?
The Handbook provides basic information about genetics in clear language.
These links provide additional genetics resources that may be useful.
What glossary definitions help with understanding LIPA?
acids ; adenine ; adrenal glands ; bone marrow ; cell ; cholesterol ; deletion ; DNA ; enzyme ; esters ; exon ; gene ; guanine ; HDL ; hydrolase ; intestine ; lipase ; lymph ; mutation ; nucleotide ; protein ; splice-site mutation ; triglycerides
You may find definitions for these and many other terms in the Genetics Home Reference Glossary.
See also Understanding Medical Terminology.
References (8 links)