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Reviewed March 2008
What is the official name of the LIMK1 gene?
The official name of this gene is “LIM domain kinase 1.”
LIMK1 is the gene's official symbol. The LIMK1 gene is also known by other names, listed below.
Read more about gene names and symbols on the About page.
What is the normal function of the LIMK1 gene?
The LIMK1 gene provides instructions for making a protein that is highly active in the brain, where it is thought to be involved in the development of nerve cells. Studies suggest that this protein may play an important role in areas of the brain that are responsible for processing visual-spatial information (visuospatial constructive cognition). These parts of the brain are important for visualizing an object as a set of parts and performing tasks such as writing, drawing, constructing models, and assembling puzzles.
Within cells, the LIMK1 protein likely regulates aspects of the cytoskeleton, the structural framework that helps to determine cell shape, size, and movement. The LIMK1 protein helps control the organization of actin filaments, which are long, thin fibers that make up a significant part of the cytoskeleton. Actin filaments are necessary for several normal cellular functions, such as cell division, cell movement (motility), maintenance of cell shape, transport of proteins and other molecules within cells, and chemical signaling between cells.
How are changes in the LIMK1 gene related to health conditions?
Where is the LIMK1 gene located?
Cytogenetic Location: 7q11.23
Molecular Location on chromosome 7: base pairs 74,083,777 to 74,122,525
(Homo sapiens Annotation Release 107, GRCh38.p2) (
The LIMK1 gene is located on the long (q) arm of chromosome 7 at position 11.23.
More precisely, the LIMK1 gene is located from base pair 74,083,777 to base pair 74,122,525 on chromosome 7.
See How do geneticists indicate the location of a gene? in the Handbook.
Where can I find additional information about LIMK1?
You and your healthcare professional may find the following resources about LIMK1 helpful.
You may also be interested in these resources, which are designed for genetics professionals and researchers.
What other names do people use for the LIMK1 gene or gene products?
See How are genetic conditions and genes named? in the Handbook.
Where can I find general information about genes?
The Handbook provides basic information about genetics in clear language.
These links provide additional genetics resources that may be useful.
What glossary definitions help with understanding LIMK1?
You may find definitions for these and many other terms in the Genetics Home Reference Glossary.
See also Understanding Medical Terminology.
References (13 links)
The resources on this site should not be used as a substitute for professional medical care or advice. Users seeking information about a personal genetic disease, syndrome, or condition should consult with a qualified healthcare professional. See How can I find a genetics professional in my area? in the Handbook.