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Reviewed August 2012
What is the official name of the LHCGR gene?
The official name of this gene is “luteinizing hormone/choriogonadotropin receptor.”
LHCGR is the gene's official symbol. The LHCGR gene is also known by other names, listed below.
Read more about gene names and symbols on the About page.
What is the normal function of the LHCGR gene?
The LHCGR gene provides instructions for making a receptor protein called the luteinizing hormone/chorionic gonadotropin receptor. Receptor proteins have specific sites into which certain other proteins, called ligands, fit like keys into locks. Together, ligands and their receptors trigger signals that affect cell development and function.
The protein produced from the LHCGR gene acts as a receptor for two ligands: luteinizing hormone and a similar hormone called chorionic gonadotropin. The receptor allows the body to respond appropriately to these hormones. In males, chorionic gonadotropin stimulates the development of cells in the testes called Leydig cells, and luteinizing hormone triggers these cells to produce androgens. Androgens, including testosterone, are the hormones that control male sexual development and reproduction. In females, luteinizing hormone triggers the release of egg cells from the ovaries (ovulation); chorionic gonadotropin is produced during pregnancy and helps maintain conditions necessary for the pregnancy to continue.
How are changes in the LHCGR gene related to health conditions?
Where is the LHCGR gene located?
Cytogenetic Location: 2p21
Molecular Location on chromosome 2: base pairs 48,686,774 to 48,755,741
The LHCGR gene is located on the short (p) arm of chromosome 2 at position 21.
More precisely, the LHCGR gene is located from base pair 48,686,774 to base pair 48,755,741 on chromosome 2.
See How do geneticists indicate the location of a gene? in the Handbook.
Where can I find additional information about LHCGR?
You and your healthcare professional may find the following resources about LHCGR helpful.
You may also be interested in these resources, which are designed for genetics professionals and researchers.
What other names do people use for the LHCGR gene or gene products?
See How are genetic conditions and genes named? in the Handbook.
Where can I find general information about genes?
The Handbook provides basic information about genetics in clear language.
These links provide additional genetics resources that may be useful.
What glossary definitions help with understanding LHCGR?
acids ; amino acid ; amino acid sequence ; androgens ; bifid ; cell ; chromosome ; constitutive ; egg ; familial ; gene ; genitalia ; groin ; hormone ; hypoplasia ; hypospadias ; infertility ; inherit ; menstruation ; micropenis ; pelvis ; precursor ; protein ; puberty ; receptor ; reproduction ; scrotum ; testes ; testosterone
You may find definitions for these and many other terms in the Genetics Home Reference Glossary.
See also Understanding Medical Terminology.
References (7 links)
The resources on this site should not be used as a substitute for professional medical care or advice. Users seeking information about a personal genetic disease, syndrome, or condition should consult with a qualified healthcare professional. See How can I find a genetics professional in my area? in the Handbook.