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Reviewed July 2008
What is the official name of the LGI1 gene?
The official name of this gene is “leucine-rich, glioma inactivated 1.”
LGI1 is the gene's official symbol. The LGI1 gene is also known by other names, listed below.
Read more about gene names and symbols on the About page.
What is the normal function of the LGI1 gene?
The LGI1 gene provides instructions for making a protein called leucine-rich, glioma inactivated 1 (Lgi1) or epitempin. This protein is found primarily in nerve cells (neurons) in the brain, including a part of the brain called the lateral temporal lobe. The temporal lobe of the brain is involved in hearing, speech, memory, and emotion.
Although researchers have proposed several functions for epitempin, its precise role in the brain remains uncertain. This protein is probably involved in normal brain development.
Some studies have suggested that epitempin plays a role in the normal function of potassium channels in neurons. These channels are embedded in the cell membrane, where they transport charged potassium atoms (potassium ions) out of neurons. Potassium channels are critical for normal electrical signaling in these cells. Other studies have found that epitempin is transported (secreted) out of neurons. The function of this protein outside cells is unclear.
Epitempin may also help regulate the communication between neurons. Researchers have determined that epitempin attaches (binds) to a receptor protein called ADAM22 on the surface of neurons. Together, these proteins help control the release of certain brain chemicals called neurotransmitters. These chemicals allow neighboring neurons to communicate with each other, which is how signals are relayed throughout the brain.
How are changes in the LGI1 gene related to health conditions?
Where is the LGI1 gene located?
Cytogenetic Location: 10q24
Molecular Location on chromosome 10: base pairs 93,757,809 to 93,798,159
(Homo sapiens Annotation Release 107, GRCh38.p2) (
The LGI1 gene is located on the long (q) arm of chromosome 10 at position 24.
More precisely, the LGI1 gene is located from base pair 93,757,809 to base pair 93,798,159 on chromosome 10.
See How do geneticists indicate the location of a gene? in the Handbook.
Where can I find additional information about LGI1?
You and your healthcare professional may find the following resources about LGI1 helpful.
You may also be interested in these resources, which are designed for genetics professionals and researchers.
What other names do people use for the LGI1 gene or gene products?
See How are genetic conditions and genes named? in the Handbook.
Where can I find general information about genes?
The Handbook provides basic information about genetics in clear language.
These links provide additional genetics resources that may be useful.
What glossary definitions help with understanding LGI1?
amino acid ; auditory ; autosomal ; autosomal dominant ; cell ; cell membrane ; epilepsy ; gene ; glioma ; ions ; leucine ; neurotransmitters ; potassium ; progression ; protein ; receptor ; seizure ; tumor
You may find definitions for these and many other terms in the Genetics Home Reference Glossary.
See also Understanding Medical Terminology.
References (13 links)
The resources on this site should not be used as a substitute for professional medical care or advice. Users seeking information about a personal genetic disease, syndrome, or condition should consult with a qualified healthcare professional. See How can I find a genetics professional in my area? in the Handbook.