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Reviewed April 2011
What is the official name of the LAMP2 gene?
The official name of this gene is “lysosomal-associated membrane protein 2.”
LAMP2 is the gene's official symbol. The LAMP2 gene is also known by other names, listed below.
Read more about gene names and symbols on the About page.
What is the normal function of the LAMP2 gene?
The LAMP2 gene provides instructions for making a protein called lysosomal associated membrane protein-2 (LAMP-2), which, as its name suggests, is found in the membrane of cellular structures called lysosomes. Lysosomes are compartments in the cell that digest and recycle materials. The role the LAMP-2 protein plays in the lysosome is unclear. Some researchers think the LAMP-2 protein may help transport cellular materials or digestive enzymes into the lysosome. The transport of cellular materials into lysosomes requires the formation of cellular structures called autophagic vacuoles (or autophagosomes). Cellular material that will be degraded in a lysosome is first enclosed in an autophagic vacuole inside the cell. The autophagic vacuole attaches (fuses) to a lysosome to transfer the cellular material into the lysosome where it can be broken down. The LAMP-2 protein may be involved in the fusion between autophagic vacuoles and lysosomes.
Slightly different versions (isoforms) of the LAMP-2 protein are produced: LAMP-2A, LAMP-2B, and LAMP-2C. These isoforms are found in different tissues throughout the body. LAMP-2B is the main isoform found in the heart and the muscles used for movement (skeletal muscles).
Does the LAMP2 gene share characteristics with other genes?
The LAMP2 gene belongs to a family of genes called CD (CD molecules).
A gene family is a group of genes that share important characteristics. Classifying individual genes into families helps researchers describe how genes are related to each other. For more information, see What are gene families? in the Handbook.
How are changes in the LAMP2 gene related to health conditions?
Where is the LAMP2 gene located?
Cytogenetic Location: Xq24
Molecular Location on the X chromosome: base pairs 120,426,148 to 120,469,349
The LAMP2 gene is located on the long (q) arm of the X chromosome at position 24.
More precisely, the LAMP2 gene is located from base pair 120,426,148 to base pair 120,469,349 on the X chromosome.
See How do geneticists indicate the location of a gene? in the Handbook.
Where can I find additional information about LAMP2?
You and your healthcare professional may find the following resources about LAMP2 helpful.
You may also be interested in these resources, which are designed for genetics professionals and researchers.
What other names do people use for the LAMP2 gene or gene products?
See How are genetic conditions and genes named? in the Handbook.
Where can I find general information about genes?
The Handbook provides basic information about genetics in clear language.
These links provide additional genetics resources that may be useful.
What glossary definitions help with understanding LAMP2?
You may find definitions for these and many other terms in the Genetics Home Reference Glossary.
See also Understanding Medical Terminology.
References (8 links)
The resources on this site should not be used as a substitute for professional medical care or advice. Users seeking information about a personal genetic disease, syndrome, or condition should consult with a qualified healthcare professional. See How can I find a genetics professional in my area? in the Handbook.