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Reviewed September 2009
What is the official name of the LAMB3 gene?
The official name of this gene is “laminin, beta 3.”
LAMB3 is the gene's official symbol. The LAMB3 gene is also known by other names, listed below.
Read more about gene names and symbols on the About page.
What is the normal function of the LAMB3 gene?
The LAMB3 gene provides instructions for making one part (subunit) of a protein called laminin 332 (formerly known as laminin 5). This protein is made up of three subunits, called alpha, beta, and gamma. The LAMB3 gene carries instructions for the beta subunit; the alpha and gamma subunits are produced from other genes.
Laminins are a group of proteins that regulate cell growth, cell movement (motility), and the attachment of cells to one another (adhesion). They are also involved in the formation and organization of basement membranes, which are thin, sheet-like structures that separate and support cells in many tissues. Laminin 332 has a particularly important role in the basement membrane that underlies the top layer of skin (the epidermis). This membrane gives strength and resiliency to the skin and creates an additional barrier between the body and its surrounding environment. Laminin 332 is a major component of fibers called anchoring filaments, which connect the two layers of the basement membrane and help hold the skin together.
Studies suggest that laminin 332 also has several other functions. This protein appears to be important for wound healing. Additionally, researchers have proposed roles for laminin 332 in the clear outer covering of the eye (the cornea) and in the development of tooth enamel.
Does the LAMB3 gene share characteristics with other genes?
The LAMB3 gene belongs to a family of genes called LAM (laminins).
A gene family is a group of genes that share important characteristics. Classifying individual genes into families helps researchers describe how genes are related to each other. For more information, see What are gene families? in the Handbook.
How are changes in the LAMB3 gene related to health conditions?
Genetics Home Reference provides information about amelogenesis imperfecta, which is also associated with changes in the LAMB3 gene.
Where is the LAMB3 gene located?
Cytogenetic Location: 1q32
Molecular Location on chromosome 1: base pairs 209,614,870 to 209,652,475
The LAMB3 gene is located on the long (q) arm of chromosome 1 at position 32.
More precisely, the LAMB3 gene is located from base pair 209,614,870 to base pair 209,652,475 on chromosome 1.
See How do geneticists indicate the location of a gene? in the Handbook.
Where can I find additional information about LAMB3?
You and your healthcare professional may find the following resources about LAMB3 helpful.
You may also be interested in these resources, which are designed for genetics professionals and researchers.
What other names do people use for the LAMB3 gene or gene products?
See How are genetic conditions and genes named? in the Handbook.
Where can I find general information about genes?
The Handbook provides basic information about genetics in clear language.
These links provide additional genetics resources that may be useful.
What glossary definitions help with understanding LAMB3?
You may find definitions for these and many other terms in the Genetics Home Reference Glossary.
See also Understanding Medical Terminology.
References (10 links)
The resources on this site should not be used as a substitute for professional medical care or advice. Users seeking information about a personal genetic disease, syndrome, or condition should consult with a qualified healthcare professional. See How can I find a genetics professional in my area? in the Handbook.