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Reviewed March 2012
What is the official name of the KRT81 gene?
The official name of this gene is “keratin 81, type II.”
KRT81 is the gene's official symbol. The KRT81 gene is also known by other names, listed below.
Read more about gene names and symbols on the About page.
What is the normal function of the KRT81 gene?
The KRT81 gene provides instructions for making the type II hair keratin K81 protein (K81). This protein belongs to a group of proteins known as keratins, which are tough, fibrous proteins that form the structural framework of cells that make up the hair, skin, and nails. Each keratin protein partners with another keratin protein to form molecules called intermediate filaments. These filaments assemble into strong networks that provide strength and resiliency to the tissues and protect them from being damaged by everyday physical stresses. The K81 protein is found in cells that make up the inner compartment of the hair shaft known as the cortex, and this protein helps give hair its strength and elasticity.
Does the KRT81 gene share characteristics with other genes?
The KRT81 gene belongs to a family of genes called KRT (keratins).
A gene family is a group of genes that share important characteristics. Classifying individual genes into families helps researchers describe how genes are related to each other. For more information, see What are gene families? in the Handbook.
How are changes in the KRT81 gene related to health conditions?
Where is the KRT81 gene located?
Cytogenetic Location: 12q13
Molecular Location on chromosome 12: base pairs 52,285,913 to 52,308,410
(Homo sapiens Annotation Release 107, GRCh38.p2) (
The KRT81 gene is located on the long (q) arm of chromosome 12 at position 13.
More precisely, the KRT81 gene is located from base pair 52,285,913 to base pair 52,308,410 on chromosome 12.
See How do geneticists indicate the location of a gene? in the Handbook.
Where can I find additional information about KRT81?
You and your healthcare professional may find the following resources about KRT81 helpful.
You may also be interested in these resources, which are designed for genetics professionals and researchers.
What other names do people use for the KRT81 gene or gene products?
See How are genetic conditions and genes named? in the Handbook.
Where can I find general information about genes?
The Handbook provides basic information about genetics in clear language.
These links provide additional genetics resources that may be useful.
What glossary definitions help with understanding KRT81?
You may find definitions for these and many other terms in the Genetics Home Reference Glossary.
See also Understanding Medical Terminology.
References (6 links)
The resources on this site should not be used as a substitute for professional medical care or advice. Users seeking information about a personal genetic disease, syndrome, or condition should consult with a qualified healthcare professional. See How can I find a genetics professional in my area? in the Handbook.