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Reviewed August 2012
What is the official name of the KRT6B gene?
The official name of this gene is “keratin 6B, type II.”
KRT6B is the gene's official symbol. The KRT6B gene is also known by other names, listed below.
Read more about gene names and symbols on the About page.
What is the normal function of the KRT6B gene?
The KRT6B gene provides instructions for making a protein called keratin 6b or K6b. Keratins are a group of tough, fibrous proteins that form the structural framework of certain cells, particularly cells that make up the skin, hair, and nails. Keratin 6b is produced in the nails, the hair follicles, and the skin on the palms of the hands and soles of the feet. It is also found in the skin's sebaceous glands, which produce an oily substance called sebum.
Keratin 6b partners with a similar protein, keratin 17, to form molecules called keratin intermediate filaments. These filaments assemble into dense networks that provide strength and resilience to the skin, nails, and other tissues. Networks of keratin filaments protect these tissues from being damaged by friction and other everyday physical stresses. Keratin 6b is also among several keratins involved in wound healing.
Does the KRT6B gene share characteristics with other genes?
The KRT6B gene belongs to a family of genes called KRT (keratins).
A gene family is a group of genes that share important characteristics. Classifying individual genes into families helps researchers describe how genes are related to each other. For more information, see What are gene families? in the Handbook.
How are changes in the KRT6B gene related to health conditions?
Where is the KRT6B gene located?
Cytogenetic Location: 12q13.13
Molecular Location on chromosome 12: base pairs 52,446,651 to 52,452,126
(Homo sapiens Annotation Release 107, GRCh38.p2) (
The KRT6B gene is located on the long (q) arm of chromosome 12 at position 13.13.
More precisely, the KRT6B gene is located from base pair 52,446,651 to base pair 52,452,126 on chromosome 12.
See How do geneticists indicate the location of a gene? in the Handbook.
Where can I find additional information about KRT6B?
You and your healthcare professional may find the following resources about KRT6B helpful.
You may also be interested in these resources, which are designed for genetics professionals and researchers.
What other names do people use for the KRT6B gene or gene products?
See How are genetic conditions and genes named? in the Handbook.
Where can I find general information about genes?
The Handbook provides basic information about genetics in clear language.
These links provide additional genetics resources that may be useful.
What glossary definitions help with understanding KRT6B?
You may find definitions for these and many other terms in the Genetics Home Reference Glossary.
See also Understanding Medical Terminology.
References (6 links)
The resources on this site should not be used as a substitute for professional medical care or advice. Users seeking information about a personal genetic disease, syndrome, or condition should consult with a qualified healthcare professional. See How can I find a genetics professional in my area? in the Handbook.