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Reviewed August 2012
What is the official name of the KRT3 gene?
The official name of this gene is “keratin 3, type II.”
KRT3 is the gene's official symbol. The KRT3 gene is also known by other names, listed below.
Read more about gene names and symbols on the About page.
What is the normal function of the KRT3 gene?
The KRT3 gene provides instructions for making a protein called keratin 3. Keratins are a group of tough, fibrous proteins that form the structural framework of epithelial cells, which are cells that line the surfaces and cavities of the body. Keratin 3 is produced in a tissue on the surface of the eye called the corneal epithelium. This tissue forms the outermost layer of the cornea, which is the clear front covering of the eye. The corneal epithelium acts as a barrier to help prevent foreign materials, such as dust and bacteria, from entering the eye.
The keratin 3 protein partners with another keratin protein, keratin 12, to form molecules known as intermediate filaments. These filaments assemble into strong networks that provide strength and resilience to the corneal epithelium.
Does the KRT3 gene share characteristics with other genes?
The KRT3 gene belongs to a family of genes called KRT (keratins).
A gene family is a group of genes that share important characteristics. Classifying individual genes into families helps researchers describe how genes are related to each other. For more information, see What are gene families? in the Handbook.
How are changes in the KRT3 gene related to health conditions?
Where is the KRT3 gene located?
Cytogenetic Location: 12q13.13
Molecular Location on chromosome 12: base pairs 52,789,685 to 52,805,717
(Homo sapiens Annotation Release 107, GRCh38.p2) (
The KRT3 gene is located on the long (q) arm of chromosome 12 at position 13.13.
More precisely, the KRT3 gene is located from base pair 52,789,685 to base pair 52,805,717 on chromosome 12.
See How do geneticists indicate the location of a gene? in the Handbook.
Where can I find additional information about KRT3?
You and your healthcare professional may find the following resources about KRT3 helpful.
You may also be interested in these resources, which are designed for genetics professionals and researchers.
What other names do people use for the KRT3 gene or gene products?
See How are genetic conditions and genes named? in the Handbook.
Where can I find general information about genes?
The Handbook provides basic information about genetics in clear language.
These links provide additional genetics resources that may be useful.
What glossary definitions help with understanding KRT3?
You may find definitions for these and many other terms in the Genetics Home Reference Glossary.
See also Understanding Medical Terminology.
References (4 links)
The resources on this site should not be used as a substitute for professional medical care or advice. Users seeking information about a personal genetic disease, syndrome, or condition should consult with a qualified healthcare professional. See How can I find a genetics professional in my area? in the Handbook.