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Genetics Home Reference: your guide to understanding genetic conditions
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KRT16

Reviewed December 2015

What is the official name of the KRT16 gene?

The official name of this gene is “keratin 16, type I.”

KRT16 is the gene's official symbol. The KRT16 gene is also known by other names, listed below.

What is the normal function of the KRT16 gene?

The KRT16 gene provides instructions for making a protein called keratin 16 or K16. Keratins are a group of tough, fibrous proteins that form the structural framework of certain cells, particularly cells that make up the skin, hair, and nails. Keratin 16 is produced in the nails, the skin on the palms of the hands and soles of the feet, and the oral mucosa that lines the inside of the mouth.

Keratin 16 partners with a similar protein, keratin 6a, to form molecules called keratin intermediate filaments. These filaments assemble into dense networks that provide strength and resilience to the skin, nails, and other tissues. Networks of keratin intermediate filaments protect these tissues from being damaged by friction and other everyday physical stresses. Keratin 16 is also among several keratins involved in wound healing.

Does the KRT16 gene share characteristics with other genes?

The KRT16 gene belongs to a family of genes called KRT (keratins).

A gene family is a group of genes that share important characteristics. Classifying individual genes into families helps researchers describe how genes are related to each other. For more information, see What are gene families? (http://ghr.nlm.nih.gov/handbook/howgeneswork/genefamilies) in the Handbook.

How are changes in the KRT16 gene related to health conditions?

pachyonychia congenita - caused by mutations in the KRT16 gene

At least 19 mutations in the KRT16 gene have been identified in people with pachyonychia congenita, a rare condition that primarily affects the nails and skin. In most cases, this condition becomes apparent within the first few months of life. Most of the KRT16 gene mutations associated with pachyonychia congenita change single protein building blocks (amino acids) in keratin 16. A few mutations delete a small number of amino acids from the protein.

The KRT16 gene mutations responsible for pachyonychia congenita change the structure of keratin 16, preventing it from interacting effectively with keratin 6a and interfering with the assembly of the keratin intermediate filament network. Without this network, skin cells become fragile and are easily damaged, making the skin less resistant to friction and minor trauma. Even normal activities such as walking can cause skin cells to break down, resulting in the formation of severe, painful blisters and calluses. Additionally, fragile skin cells may abnormally produce more keratin in response to damage, which makes the skin problems worse. Defective keratin 16 also disrupts the growth and function of other tissues, such as the hair follicles and nails, which explains why the signs and symptoms of pachyonychia congenita can also affect these other parts of the body.

Where is the KRT16 gene located?

Cytogenetic Location: 17q21.2

Molecular Location on chromosome 17: base pairs 41,609,778 to 41,612,827

(Homo sapiens Annotation Release 107, GRCh38.p2) (NCBI (http://www.ncbi.nlm.nih.gov/gene/3868))

The KRT16 gene is located on the long (q) arm of chromosome 17 at position 21.2.

The KRT16 gene is located on the long (q) arm of chromosome 17 at position 21.2.

More precisely, the KRT16 gene is located from base pair 41,609,778 to base pair 41,612,827 on chromosome 17.

See How do geneticists indicate the location of a gene? (http://ghr.nlm.nih.gov/handbook/howgeneswork/genelocation) in the Handbook.

Where can I find additional information about KRT16?

You and your healthcare professional may find the following resources about KRT16 helpful.

You may also be interested in these resources, which are designed for genetics professionals and researchers.

What other names do people use for the KRT16 gene or gene products?

  • CK16
  • cytokeratin 16
  • cytokeratin-16
  • K1C16_HUMAN
  • K1CP
  • K16
  • keratin 16
  • keratin-16
  • keratin 16 (focal non-epidermolytic palmoplantar keratoderma)
  • keratin, type I cytoskeletal 16
  • KRT16A
  • NEPPK

See How are genetic conditions and genes named? (http://ghr.nlm.nih.gov/handbook/mutationsanddisorders/naming) in the Handbook.

What glossary definitions help with understanding KRT16?

acids ; cytokeratin ; domain ; gene ; intermediate filaments ; keratin ; keratoderma ; motif ; mucosa ; pachyonychia ; palmoplantar keratoderma ; protein ; resilience ; trauma

You may find definitions for these and many other terms in the Genetics Home Reference Glossary.

References

  • Fu T, Leachman SA, Wilson NJ, Smith FJ, Schwartz ME, Tang JY. Genotype-phenotype correlations among pachyonychia congenita patients with K16 mutations. J Invest Dermatol. 2011 May;131(5):1025-8. doi: 10.1038/jid.2010.373. Epub 2010 Dec 16. (http://www.ncbi.nlm.nih.gov/pubmed/21160496?dopt=Abstract)
  • McLean WH, Hansen CD, Eliason MJ, Smith FJ. The phenotypic and molecular genetic features of pachyonychia congenita. J Invest Dermatol. 2011 May;131(5):1015-7. doi: 10.1038/jid.2011.59. Epub 2011 Mar 24. Review. (http://www.ncbi.nlm.nih.gov/pubmed/21430705?dopt=Abstract)
  • McLean WH, Rugg EL, Lunny DP, Morley SM, Lane EB, Swensson O, Dopping-Hepenstal PJ, Griffiths WA, Eady RA, Higgins C, et al. Keratin 16 and keratin 17 mutations cause pachyonychia congenita. Nat Genet. 1995 Mar;9(3):273-8. (http://www.ncbi.nlm.nih.gov/pubmed/7539673?dopt=Abstract)
  • NCBI Gene (http://www.ncbi.nlm.nih.gov/gene/3868)
  • Paladini RD, Takahashi K, Gant TM, Coulombe PA. cDNA cloning and bacterial expression of the human type I keratin 16. Biochem Biophys Res Commun. 1995 Oct 13;215(2):517-23. (http://www.ncbi.nlm.nih.gov/pubmed/7487986?dopt=Abstract)
  • Smith FJ, Fisher MP, Healy E, Rees JL, Bonifas JM, Epstein EH Jr, Tan EM, Uitto J, McLean WH. Novel keratin 16 mutations and protein expression studies in pachyonychia congenita type 1 and focal palmoplantar keratoderma. Exp Dermatol. 2000 Jun;9(3):170-7. (http://www.ncbi.nlm.nih.gov/pubmed/10839714?dopt=Abstract)
  • Smith FJ, Liao H, Cassidy AJ, Stewart A, Hamill KJ, Wood P, Joval I, van Steensel MA, Björck E, Callif-Daley F, Pals G, Collins P, Leachman SA, Munro CS, McLean WH. The genetic basis of pachyonychia congenita. J Investig Dermatol Symp Proc. 2005 Oct;10(1):21-30. Review. (http://www.ncbi.nlm.nih.gov/pubmed/16250206?dopt=Abstract)
  • Terrinoni A, Smith FJ, Didona B, Canzona F, Paradisi M, Huber M, Hohl D, David A, Verloes A, Leigh IM, Munro CS, Melino G, McLean WH. Novel and recurrent mutations in the genes encoding keratins K6a, K16 and K17 in 13 cases of pachyonychia congenita. J Invest Dermatol. 2001 Dec;117(6):1391-6. (http://www.ncbi.nlm.nih.gov/pubmed/11886499?dopt=Abstract)
  • Wilson NJ, O'Toole EA, Milstone LM, Hansen CD, Shepherd AA, Al-Asadi E, Schwartz ME, McLean WH, Sprecher E, Smith FJ. The molecular genetic analysis of the expanding pachyonychia congenita case collection. Br J Dermatol. 2014 Aug;171(2):343-55. doi: 10.1111/bjd.12958. Epub 2014 Aug 6. (http://www.ncbi.nlm.nih.gov/pubmed/24611874?dopt=Abstract)

 

The resources on this site should not be used as a substitute for professional medical care or advice. Users seeking information about a personal genetic disease, syndrome, or condition should consult with a qualified healthcare professional. See How can I find a genetics professional in my area? (http://ghr.nlm.nih.gov/handbook/consult/findingprofessional) in the Handbook.

 
Reviewed: December 2015
Published: February 1, 2016