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Reviewed May 2013
What is the official name of the KRT14 gene?
The official name of this gene is “keratin 14, type I.”
KRT14 is the gene's official symbol. The KRT14 gene is also known by other names, listed below.
Read more about gene names and symbols on the About page.
What is the normal function of the KRT14 gene?
The KRT14 gene provides instructions for making a protein called keratin 14. Keratins are a group of tough, fibrous proteins that form the structural framework of certain cells, particularly cells that make up the skin, hair, and nails. Keratin 14 is specifically produced in cells called keratinocytes in the outer layer of the skin (the epidermis).
Keratin 14 partners with a similar protein, keratin 5 (produced from the KRT5 gene), to form molecules called keratin intermediate filaments. These filaments assemble into strong networks that help attach keratinocytes together and anchor the epidermis to underlying layers of skin. The network of keratin intermediate filaments provides strength and resiliency to the skin and protects it from being damaged by friction and other everyday physical stresses.
Researchers believe that keratin 14 may also play a role in the formation of sweat glands and the development of patterned ridges on the skin of the hands and feet. These ridges, called dermatoglyphs, are the basis for each person's unique fingerprints.
Does the KRT14 gene share characteristics with other genes?
The KRT14 gene belongs to a family of genes called KRT (keratins).
A gene family is a group of genes that share important characteristics. Classifying individual genes into families helps researchers describe how genes are related to each other. For more information, see What are gene families? in the Handbook.
How are changes in the KRT14 gene related to health conditions?
Where is the KRT14 gene located?
Cytogenetic Location: 17q21.2
Molecular Location on chromosome 17: base pairs 41,582,278 to 41,586,894
The KRT14 gene is located on the long (q) arm of chromosome 17 at position 21.2.
More precisely, the KRT14 gene is located from base pair 41,582,278 to base pair 41,586,894 on chromosome 17.
See How do geneticists indicate the location of a gene? in the Handbook.
Where can I find additional information about KRT14?
You and your healthcare professional may find the following resources about KRT14 helpful.
You may also be interested in these resources, which are designed for genetics professionals and researchers.
What other names do people use for the KRT14 gene or gene products?
See How are genetic conditions and genes named? in the Handbook.
Where can I find general information about genes?
The Handbook provides basic information about genetics in clear language.
These links provide additional genetics resources that may be useful.
What glossary definitions help with understanding KRT14?
You may find definitions for these and many other terms in the Genetics Home Reference Glossary.
See also Understanding Medical Terminology.
References (11 links)
The resources on this site should not be used as a substitute for professional medical care or advice. Users seeking information about a personal genetic disease, syndrome, or condition should consult with a qualified healthcare professional. See How can I find a genetics professional in my area? in the Handbook.