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Reviewed February 2014
What is the official name of the KRT10 gene?
The official name of this gene is “keratin 10, type I.”
KRT10 is the gene's official symbol. The KRT10 gene is also known by other names, listed below.
Read more about gene names and symbols on the About page.
What is the normal function of the KRT10 gene?
The KRT10 gene provides instructions for making a protein called keratin 10. Keratins are a group of tough, fibrous proteins that form the structural framework of cells called keratinocytes that make up the skin, hair, and nails. Keratin 10 is produced in keratinocytes in the outer layer of the skin (the epidermis).
In the fluid-filled space inside these cells (the cytoplasm), the keratin 10 protein partners with a similar protein, keratin 1 (produced from the KRT1 gene), to form molecules called keratin intermediate filaments. These filaments assemble into strong networks that provide strength and resiliency to the skin and protect it from being damaged by friction and other everyday physical stresses.
Does the KRT10 gene share characteristics with other genes?
The KRT10 gene belongs to a family of genes called KRT (keratins).
A gene family is a group of genes that share important characteristics. Classifying individual genes into families helps researchers describe how genes are related to each other. For more information, see What are gene families? in the Handbook.
How are changes in the KRT10 gene related to health conditions?
Where is the KRT10 gene located?
Cytogenetic Location: 17q21
Molecular Location on chromosome 17: base pairs 40,818,116 to 40,822,617
The KRT10 gene is located on the long (q) arm of chromosome 17 at position 21.
More precisely, the KRT10 gene is located from base pair 40,818,116 to base pair 40,822,617 on chromosome 17.
See How do geneticists indicate the location of a gene? in the Handbook.
Where can I find additional information about KRT10?
You and your healthcare professional may find the following resources about KRT10 helpful.
You may also be interested in these resources, which are designed for genetics professionals and researchers.
What other names do people use for the KRT10 gene or gene products?
See How are genetic conditions and genes named? in the Handbook.
Where can I find general information about genes?
The Handbook provides basic information about genetics in clear language.
These links provide additional genetics resources that may be useful.
What glossary definitions help with understanding KRT10?
amino acid ; amino acid sequence ; arginine ; cell ; congenital ; cytokeratin ; cytoplasm ; epidermis ; erythroderma ; gene ; ichthyosiform ; ichthyosis ; intermediate filaments ; keratin ; mosaicism ; nucleus ; protein ; trauma
You may find definitions for these and many other terms in the Genetics Home Reference Glossary.
See also Understanding Medical Terminology.
References (9 links)
The resources on this site should not be used as a substitute for professional medical care or advice. Users seeking information about a personal genetic disease, syndrome, or condition should consult with a qualified healthcare professional. See How can I find a genetics professional in my area? in the Handbook.