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Reviewed October 2012
What is the official name of the KLLN gene?
The official name of this gene is “killin, p53-regulated DNA replication inhibitor.”
KLLN is the gene's official symbol. The KLLN gene is also known by other names, listed below.
Read more about gene names and symbols on the About page.
What is the normal function of the KLLN gene?
The KLLN gene provides instructions for making a protein called killin. The activity of the KLLN gene is controlled by a protein called p53 (which is produced from the TP53 gene). Little is known about the function of killin, although it is thought to trigger cells to self-destruct (undergo apoptosis) when they are damaged or no longer needed. In this way, killin helps to prevent abnormal cells from growing and dividing unchecked to form tumors. Based on this role, killin is thought to be a tumor suppressor.
How are changes in the KLLN gene related to health conditions?
Where is the KLLN gene located?
Cytogenetic Location: 10q23
Molecular Location on chromosome 10: base pairs 87,859,160 to 87,863,436
The KLLN gene is located on the long (q) arm of chromosome 10 at position 23.
More precisely, the KLLN gene is located from base pair 87,859,160 to base pair 87,863,436 on chromosome 10.
See How do geneticists indicate the location of a gene? in the Handbook.
Where can I find additional information about KLLN?
You and your healthcare professional may find the following resources about KLLN helpful.
You may also be interested in these resources, which are designed for genetics professionals and researchers.
What other names do people use for the KLLN gene or gene products?
See How are genetic conditions and genes named? in the Handbook.
Where can I find general information about genes?
The Handbook provides basic information about genetics in clear language.
These links provide additional genetics resources that may be useful.
What glossary definitions help with understanding KLLN?
You may find definitions for these and many other terms in the Genetics Home Reference Glossary.
See also Understanding Medical Terminology.
References (4 links)