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Reviewed October 2011
What is the official name of the KIF1B gene?
The official name of this gene is “kinesin family member 1B.”
KIF1B is the gene's official symbol. The KIF1B gene is also known by other names, listed below.
Read more about gene names and symbols on the About page.
What is the normal function of the KIF1B gene?
The KIF1B gene provides instructions for making a protein called kinesin family member 1B, part of the kinesin family of proteins. These proteins are essential for the transport of materials within cells. Kinesin proteins function like freight trains that transport cargo, and their structure is suited for this cargo-carrying function. One part of the protein, called the motor domain, provides the power to move the protein and its cargo along a track-like system made from structures called microtubules. Another part of the kinesin protein, which varies among members of this protein family, binds to specific materials for transport.
Research suggests that the kinesin family member 1B protein specializes in carrying two types of cargo. In nerve cells (neurons), this protein transports small, sac-like structures called synaptic vesicles, which contain materials necessary for the transmission of nerve impulses. In other cell types, the kinesin family member 1B protein carries energy-producing structures called mitochondria.
In addition to its transport functions, the kinesin family member 1B protein appears to be involved in programmed cell death (apoptosis). Apoptosis is a common process throughout life that helps the body get rid of cells it does not need.
Does the KIF1B gene share characteristics with other genes?
The KIF1B gene belongs to a family of genes called KIF (kinesins).
A gene family is a group of genes that share important characteristics. Classifying individual genes into families helps researchers describe how genes are related to each other. For more information, see What are gene families? in the Handbook.
How are changes in the KIF1B gene related to health conditions?
Where is the KIF1B gene located?
Cytogenetic Location: 1p36.2
Molecular Location on chromosome 1: base pairs 10,210,706 to 10,381,603
The KIF1B gene is located on the short (p) arm of chromosome 1 at position 36.2.
More precisely, the KIF1B gene is located from base pair 10,210,706 to base pair 10,381,603 on chromosome 1.
See How do geneticists indicate the location of a gene? in the Handbook.
Where can I find additional information about KIF1B?
You and your healthcare professional may find the following resources about KIF1B helpful.
You may also be interested in these resources, which are designed for genetics professionals and researchers.
What other names do people use for the KIF1B gene or gene products?
See How are genetic conditions and genes named? in the Handbook.
Where can I find general information about genes?
The Handbook provides basic information about genetics in clear language.
These links provide additional genetics resources that may be useful.
What glossary definitions help with understanding KIF1B?
acids ; adrenal glands ; amino acid ; apoptosis ; benign ; cell ; chromosome ; deletion ; domain ; gene ; glutamine ; hormone ; inherited ; kidney ; leucine ; mitochondria ; motor ; mutation ; nervous system ; neuroblasts ; pheochromocytoma ; protein ; synaptic vesicles ; syndrome ; tumor
You may find definitions for these and many other terms in the Genetics Home Reference Glossary.
See also Understanding Medical Terminology.
References (9 links)
The resources on this site should not be used as a substitute for professional medical care or advice. Users seeking information about a personal genetic disease, syndrome, or condition should consult with a qualified healthcare professional. See How can I find a genetics professional in my area? in the Handbook.