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Reviewed February 2013
What is the official name of the KAT6B gene?
The official name of this gene is “K(lysine) acetyltransferase 6B.”
KAT6B is the gene's official symbol. The KAT6B gene is also known by other names, listed below.
Read more about gene names and symbols on the About page.
What is the normal function of the KAT6B gene?
The KAT6B gene provides instructions for making a type of enzyme called a histone acetyltransferase. These enzymes modify histones, which are structural proteins that attach (bind) to DNA and give chromosomes their shape. By adding a small molecule called an acetyl group to particular locations on histones, histone acetyltransferases control the activity of certain genes.
Little is known about the function of the histone acetyltransferase produced from the KAT6B gene. It is active in cells and tissues throughout the body, where it interacts with many other proteins. It appears to regulate genes that are important for early development, including development of the skeleton and nervous system.
Does the KAT6B gene share characteristics with other genes?
The KAT6B gene belongs to a family of genes called chromatin-modifying enzymes (chromatin-modifying enzymes). It also belongs to a family of genes called PHF (PHD-type zinc fingers). It also belongs to a family of genes called ZC2HC (zinc fingers, C2HC-type).
A gene family is a group of genes that share important characteristics. Classifying individual genes into families helps researchers describe how genes are related to each other. For more information, see What are gene families? in the Handbook.
How are changes in the KAT6B gene related to health conditions?
Where is the KAT6B gene located?
Cytogenetic Location: 10q22.2
Molecular Location on chromosome 10: base pairs 74,824,926 to 75,032,622
The KAT6B gene is located on the long (q) arm of chromosome 10 at position 22.2.
More precisely, the KAT6B gene is located from base pair 74,824,926 to base pair 75,032,622 on chromosome 10.
See How do geneticists indicate the location of a gene? in the Handbook.
Where can I find additional information about KAT6B?
You and your healthcare professional may find the following resources about KAT6B helpful.
You may also be interested in these resources, which are designed for genetics professionals and researchers.
What other names do people use for the KAT6B gene or gene products?
See How are genetic conditions and genes named? in the Handbook.
Where can I find general information about genes?
The Handbook provides basic information about genetics in clear language.
These links provide additional genetics resources that may be useful.
What glossary definitions help with understanding KAT6B?
acute ; acute myeloid leukemia ; AML ; cancer ; cell ; chemotherapy ; chromosome ; disability ; DNA ; domain ; enzyme ; exon ; gene ; gene regulation ; histone ; infertility ; leukemia ; lysine ; molecule ; myelodysplastic syndrome ; myeloid ; nervous system ; protein ; syndrome ; translocation ; tumor
You may find definitions for these and many other terms in the Genetics Home Reference Glossary.
See also Understanding Medical Terminology.
References (10 links)
The resources on this site should not be used as a substitute for professional medical care or advice. Users seeking information about a personal genetic disease, syndrome, or condition should consult with a qualified healthcare professional. See How can I find a genetics professional in my area? in the Handbook.