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Reviewed April 2010
What is the official name of the JAG1 gene?
The official name of this gene is “jagged 1.”
JAG1 is the gene's official symbol. The JAG1 gene is also known by other names, listed below.
Read more about gene names and symbols on the About page.
What is the normal function of the JAG1 gene?
The JAG1 gene provides instructions for making a protein called Jagged-1, which is involved in an important pathway by which cells can signal to each other. The Jagged-1 protein is inserted into the membranes of certain cells. It connects with other proteins called Notch receptors, which are bound to the membranes of adjacent cells. These proteins fit together like a lock and its key. When a connection is made between the Jagged-1 and Notch proteins, it launches a series of signaling reactions (Notch signaling) affecting cell functions. Notch signaling controls how certain types of cells develop in a growing embryo, especially cells destined to be part of the heart, liver, eyes, ears, and spinal column. The Jagged-1 protein continues to play a role throughout life in the development of new blood cells.
Does the JAG1 gene share characteristics with other genes?
The JAG1 gene belongs to a family of genes called CD (CD molecules).
A gene family is a group of genes that share important characteristics. Classifying individual genes into families helps researchers describe how genes are related to each other. For more information, see What are gene families? in the Handbook.
How are changes in the JAG1 gene related to health conditions?
Where is the JAG1 gene located?
Cytogenetic Location: 20p12.1-p11.23
Molecular Location on chromosome 20: base pairs 10,637,684 to 10,674,046
The JAG1 gene is located on the short (p) arm of chromosome 20 between positions 12.1 and 11.23.
More precisely, the JAG1 gene is located from base pair 10,637,684 to base pair 10,674,046 on chromosome 20.
See How do geneticists indicate the location of a gene? in the Handbook.
Where can I find additional information about JAG1?
You and your healthcare professional may find the following resources about JAG1 helpful.
You may also be interested in these resources, which are designed for genetics professionals and researchers.
What other names do people use for the JAG1 gene or gene products?
See How are genetic conditions and genes named? in the Handbook.
Where can I find general information about genes?
The Handbook provides basic information about genetics in clear language.
These links provide additional genetics resources that may be useful.
What glossary definitions help with understanding JAG1?
You may find definitions for these and many other terms in the Genetics Home Reference Glossary.
See also Understanding Medical Terminology.
References (14 links)
The resources on this site should not be used as a substitute for professional medical care or advice. Users seeking information about a personal genetic disease, syndrome, or condition should consult with a qualified healthcare professional. See How can I find a genetics professional in my area? in the Handbook.