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Reviewed April 2014
What is the official name of the ITGB2 gene?
The official name of this gene is “integrin beta 2.”
ITGB2 is the gene's official symbol. The ITGB2 gene is also known by other names, listed below.
Read more about gene names and symbols on the About page.
What is the normal function of the ITGB2 gene?
The ITGB2 gene provides instructions for making one part (the β2 subunit) of at least four different proteins known as β2 integrins. The other subunit can be one of a variety of alpha (α) subunits that are produced from different genes. Integrins are a group of proteins that regulate the attachment of cells to one another (cell-cell adhesion) and to the surrounding network of proteins and other molecules (cell-matrix adhesion). Integrins also transmit signals that regulate cell growth and the activity of certain genes.
Integrins that contain the β2 subunit are found embedded in the membrane that surrounds white blood cells (leukocytes). β2 integrins help leukocytes gather at sites of infection or injury, where they are needed to contribute to the immune response. β2 integrins recognize signs of inflammation and attach (bind) to proteins called ligands on the lining of blood vessels. This binding leads to linkage (adhesion) of the leukocyte to the blood vessel wall. Signaling through the β2 integrins triggers the transport of the attached leukocyte across the blood vessel wall to the site of infection or injury.
Does the ITGB2 gene share characteristics with other genes?
The ITGB2 gene belongs to a family of genes called CD (CD molecules). It also belongs to a family of genes called complement (complement system). It also belongs to a family of genes called ITG (integrins).
A gene family is a group of genes that share important characteristics. Classifying individual genes into families helps researchers describe how genes are related to each other. For more information, see What are gene families? in the Handbook.
How are changes in the ITGB2 gene related to health conditions?
Where is the ITGB2 gene located?
Cytogenetic Location: 21q22.3
Molecular Location on chromosome 21: base pairs 44,885,949 to 44,928,873
The ITGB2 gene is located on the long (q) arm of chromosome 21 at position 22.3.
More precisely, the ITGB2 gene is located from base pair 44,885,949 to base pair 44,928,873 on chromosome 21.
See How do geneticists indicate the location of a gene? in the Handbook.
Where can I find additional information about ITGB2?
You and your healthcare professional may find the following resources about ITGB2 helpful.
You may also be interested in these resources, which are designed for genetics professionals and researchers.
What other names do people use for the ITGB2 gene or gene products?
See How are genetic conditions and genes named? in the Handbook.
Where can I find general information about genes?
The Handbook provides basic information about genetics in clear language.
These links provide additional genetics resources that may be useful.
What glossary definitions help with understanding ITGB2?
You may find definitions for these and many other terms in the Genetics Home Reference Glossary.
See also Understanding Medical Terminology.
References (5 links)
The resources on this site should not be used as a substitute for professional medical care or advice. Users seeking information about a personal genetic disease, syndrome, or condition should consult with a qualified healthcare professional. See How can I find a genetics professional in my area? in the Handbook.