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Reviewed September 2009
What is the official name of the ITGA6 gene?
The official name of this gene is “integrin subunit alpha 6.”
ITGA6 is the gene's official symbol. The ITGA6 gene is also known by other names, listed below.
Read more about gene names and symbols on the About page.
What is the normal function of the ITGA6 gene?
The ITGA6 gene provides instructions for making one part (the α6 subunit) of two proteins known as α6β4 integrin and α6β1 integrin. Integrins are a group of proteins that regulate the attachment of cells to one another (cell-cell adhesion) and to the surrounding network of proteins and other molecules (cell-matrix adhesion). Integrins also transmit chemical signals that regulate cell growth and the activity of certain genes.
The α6β4 integrin protein is found primarily in epithelial cells, which are cells that line the surfaces and cavities of the body. This protein plays a particularly important role in strengthening and stabilizing the skin. It is a component of hemidesmosomes, which are microscopic structures that anchor the outer layer of the skin (the epidermis) to underlying layers. As part of a complex network of proteins in hemidesmosomes, α6β4 integrin helps to hold the layers of skin together.
The other integrin made with the α6 subunit, α6β1 integrin, functions during the formation of organs and tissues before birth. The α6β1 integrin protein has not been as well studied as α6β4 integrin.
Does the ITGA6 gene share characteristics with other genes?
A gene family is a group of genes that share important characteristics. Classifying individual genes into families helps researchers describe how genes are related to each other. For more information, see What are gene families? in the Handbook.
How are changes in the ITGA6 gene related to health conditions?
Genetics Home Reference provides information about prostate cancer, which is also associated with changes in the ITGA6 gene.
Where is the ITGA6 gene located?
Cytogenetic Location: 2q31.1
Molecular Location on chromosome 2: base pairs 172,427,586 to 172,506,453
(Homo sapiens Annotation Release 107, GRCh38.p2) (
The ITGA6 gene is located on the long (q) arm of chromosome 2 at position 31.1.
More precisely, the ITGA6 gene is located from base pair 172,427,586 to base pair 172,506,453 on chromosome 2.
See How do geneticists indicate the location of a gene? in the Handbook.
Where can I find additional information about ITGA6?
You and your healthcare professional may find the following resources about ITGA6 helpful.
You may also be interested in these resources, which are designed for genetics professionals and researchers.
What other names do people use for the ITGA6 gene or gene products?
See How are genetic conditions and genes named? in the Handbook.
Where can I find general information about genes?
The Handbook provides basic information about genetics in clear language.
These links provide additional genetics resources that may be useful.
What glossary definitions help with understanding ITGA6?
antigens ; apoptosis ; atresia ; basement membrane ; cancer ; cell ; cell adhesion ; differentiation ; digestive ; epidermis ; epithelial ; extracellular ; extracellular matrix ; gene ; growth factor ; integrins ; kinase ; lymphocyte ; obstruction ; oncogene ; progression ; prostate ; protein ; pyloric ; receptor ; signal transduction ; subunit ; transduction ; transmembrane ; trauma ; vascular
You may find definitions for these and many other terms in the Genetics Home Reference Glossary.
See also Understanding Medical Terminology.
References (10 links)
The resources on this site should not be used as a substitute for professional medical care or advice. Users seeking information about a personal genetic disease, syndrome, or condition should consult with a qualified healthcare professional. See How can I find a genetics professional in my area? in the Handbook.