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Reviewed April 2013
What is the official name of the IL7R gene?
The official name of this gene is “interleukin 7 receptor.”
IL7R is the gene's official symbol. The IL7R gene is also known by other names, listed below.
Read more about gene names and symbols on the About page.
What is the normal function of the IL7R gene?
The IL7R gene provides instructions for making a protein called interleukin 7 (IL-7) receptor alpha chain. This protein is one piece of both the IL-7 receptor and the thymic stromal lymphopoietin (TSLP) receptor. These receptors are embedded in the cell membrane of immune system cells. The IL-7 receptor is found in B cells and T cells as well as the early blood-forming cells that give rise to them. The TSLP receptor is found in several types of immune cells, including B cells, T cells, monocytes, and dendritic cells. These cells identify foreign substances and defend the body against infection and disease.
At the cell surface, the IL-7 receptor interacts with a protein called IL-7. IL-7 is a cytokine, which is a protein that regulates the activity of immune system cells. The receptor and cytokine fit together like a lock and its key, triggering a series of chemical signals inside the cell. In early blood-forming cells, signaling through the IL-7 receptor ensures the development of mature B cells and T cells. IL-7 receptor signaling also stimulates the later growth and division (proliferation) and survival of these cells.
Similarly, the TSLP receptor interacts with the cytokine TSLP. Attachment of TSLP to its receptor triggers a set of signals that support proliferation and maturation of a variety of immune system cells.
Does the IL7R gene share characteristics with other genes?
The IL7R gene belongs to a family of genes called CD (CD molecules). It also belongs to a family of genes called fibronectin type III domain containing (fibronectin type III domain containing). It also belongs to a family of genes called IL (interleukins and interleukin receptors).
A gene family is a group of genes that share important characteristics. Classifying individual genes into families helps researchers describe how genes are related to each other. For more information, see What are gene families? in the Handbook.
How are changes in the IL7R gene related to health conditions?
Where is the IL7R gene located?
Cytogenetic Location: 5p13
Molecular Location on chromosome 5: base pairs 35,856,874 to 35,879,602
The IL7R gene is located on the short (p) arm of chromosome 5 at position 13.
More precisely, the IL7R gene is located from base pair 35,856,874 to base pair 35,879,602 on chromosome 5.
See How do geneticists indicate the location of a gene? in the Handbook.
Where can I find additional information about IL7R?
You and your healthcare professional may find the following resources about IL7R helpful.
You may also be interested in these resources, which are designed for genetics professionals and researchers.
What other names do people use for the IL7R gene or gene products?
See How are genetic conditions and genes named? in the Handbook.
Where can I find general information about genes?
The Handbook provides basic information about genetics in clear language.
These links provide additional genetics resources that may be useful.
What glossary definitions help with understanding IL7R?
acute ; acute lymphoblastic leukemia ; amino acid ; autoimmune ; autoimmunity ; cell ; cell membrane ; central nervous system ; cytokine ; gene ; genetic variation ; immune system ; immunodeficiency ; infection ; inflammation ; isoleucine ; leukemia ; myelin sheath ; nervous system ; NK cells ; precursor ; proliferation ; protein ; receptor ; sclerosis ; subunit ; threonine
You may find definitions for these and many other terms in the Genetics Home Reference Glossary.
See also Understanding Medical Terminology.
References (11 links)
The resources on this site should not be used as a substitute for professional medical care or advice. Users seeking information about a personal genetic disease, syndrome, or condition should consult with a qualified healthcare professional. See How can I find a genetics professional in my area? in the Handbook.