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The information on this page was automatically extracted from online scientific databases.

What is the official name of the IL6R gene?

The official name of this gene is “interleukin 6 receptor.”

IL6R is the gene's official symbol. The IL6R gene is also known by other names, listed below.

Read more about gene names and symbols on the About page.

What is the normal function of the IL6R gene?

From NCBI GeneThis link leads to a site outside Genetics Home Reference.:

This gene encodes a subunit of the interleukin 6 (IL6) receptor complex. Interleukin 6 is a potent pleiotropic cytokine that regulates cell growth and differentiation and plays an important role in the immune response. The IL6 receptor is a protein complex consisting of this protein and interleukin 6 signal transducer (IL6ST/GP130/IL6-beta), a receptor subunit also shared by many other cytokines. Dysregulated production of IL6 and this receptor are implicated in the pathogenesis of many diseases, such as multiple myeloma, autoimmune diseases and prostate cancer. Alternatively spliced transcript variants encoding distinct isoforms have been reported. A pseudogene of this gene is found on chromosome 9.[provided by RefSeq, May 2011]

From UniProt (IL6RA_HUMAN)This link leads to a site outside Genetics Home Reference.:

Part of the receptor for interleukin 6. Binds to IL6 with low affinity, but does not transduce a signal. Signal activation necessitate an association with IL6ST. Activation may lead to the regulation of the immune response, acute-phase reactions and hematopoiesis.Low concentration of a soluble form of IL6 receptor acts as an agonist of IL6 activity.

How are changes in the IL6R gene related to health conditions?

Genetics Home Reference provides information about rheumatoid arthritis, which is associated with changes in the IL6R gene.
NCBI GeneThis link leads to a site outside Genetics Home Reference. lists the following diseases or traits (phenotypes) known or believed to be associated with changes in the IL6R gene.
  • Serum level of interleukin 6
  • Serum level of interleukin-6 soluble receptor
OMIM.orgThis link leads to a site outside Genetics Home Reference., a catalog designed for genetics professionals and researchers, provides the following information about the IL6R gene and its association with health conditions.

Where is the IL6R gene located?

Cytogenetic Location: 1q21

Molecular Location on chromosome 1: base pairs 154,405,193 to 154,469,450

(Homo sapiens Annotation Release 107, GRCh38.p2) (NCBIThis link leads to a site outside Genetics Home Reference.)

The IL6R gene is located on the long (q) arm of chromosome 1 at position 21.

The IL6R gene is located on the long (q) arm of chromosome 1 at position 21.

More precisely, the IL6R gene is located from base pair 154,405,193 to base pair 154,469,450 on chromosome 1.

See How do geneticists indicate the location of a gene? in the Handbook.

Where can I find additional information about IL6R?

You and your healthcare professional may find the following resources about IL6R helpful.

You may also be interested in these resources, which are designed for genetics professionals and researchers.

What other names do people use for the IL6R gene or gene products?

  • CD126
  • gp80
  • IL6Q
  • IL-6R-1
  • IL6RA
  • IL-6RA
  • IL6RQ

Where can I find general information about genes?

The Handbook provides basic information about genetics in clear language.

These links provide additional genetics resources that may be useful.

What glossary definitions help with understanding IL6R?

acute ; autoimmune ; cancer ; cell ; chromosome ; cytokine ; differentiation ; gene ; immune response ; isoforms ; multiple myeloma ; myeloma ; pleiotropic ; prostate ; protein ; pseudogene ; receptor ; soluble ; subunit ; transcript

You may find definitions for these and many other terms in the Genetics Home Reference Glossary.

See also Understanding Medical Terminology.


The resources on this site should not be used as a substitute for professional medical care or advice. Users seeking information about a personal genetic disease, syndrome, or condition should consult with a qualified healthcare professional. See How can I find a genetics professional in my area? in the Handbook.

Published: February 8, 2016