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IL13

IL13

The information on this page was automatically extracted from online scientific databases.

What is the official name of the IL13 gene?

The official name of this gene is “interleukin 13.”

IL13 is the gene's official symbol. The IL13 gene is also known by other names, listed below.

Read more about gene names and symbols on the About page.

What is the normal function of the IL13 gene?

From NCBI GeneThis link leads to a site outside Genetics Home Reference.:

This gene encodes an immunoregulatory cytokine produced primarily by activated Th2 cells. This cytokine is involved in several stages of B-cell maturation and differentiation. It up-regulates CD23 and MHC class II expression, and promotes IgE isotype switching of B cells. This cytokine down-regulates macrophage activity, thereby inhibits the production of pro-inflammatory cytokines and chemokines. This cytokine is found to be critical to the pathogenesis of allergen-induced asthma but operates through mechanisms independent of IgE and eosinophils. This gene, IL3, IL5, IL4, and CSF2 form a cytokine gene cluster on chromosome 5q, with this gene particularly close to IL4. [provided by RefSeq, Jul 2008]

From UniProtThis link leads to a site outside Genetics Home Reference.:

Cytokine. Inhibits inflammatory cytokine production. Synergizes with IL2 in regulating interferon-gamma synthesis. May be critical in regulating inflammatory and immune responses.

NOTE: UniProtThis link leads to a site outside Genetics Home Reference. suggests using caution when interpreting this information.

How are changes in the IL13 gene related to health conditions?

Genetics Home Reference provides information about psoriatic arthritis, which is associated with changes in the IL13 gene.
UniProtThis link leads to a site outside Genetics Home Reference. provides the following information about the IL13 gene's known or predicted involvement in human disease.

Allergic rhinitis (ALRH): A common disease with complex inheritance characterized by mucosal inflammation caused by allergen exposure.[1]This link leads to a site outside Genetics Home Reference. Disease susceptibility is associated with variations affecting the gene represented in this entry.

NCBI GeneThis link leads to a site outside Genetics Home Reference. lists the following diseases or traits (phenotypes) known or believed to be associated with changes in the IL13 gene.
  • Allergic rhinitis[1]This link leads to a site outside Genetics Home Reference.
  • Asthma, susceptibility to[2]This link leads to a site outside Genetics Home Reference.
UniProt and NCBI Gene cite these articles in OMIM, a catalog designed for genetics professionals and researchers that provides detailed information about genetic conditions and genes.
 Article
Number
Main Topic
[1]
[2]

Where is the IL13 gene located?

Cytogenetic Location: 5q31

Molecular Location on chromosome 5: base pairs 132,658,172 to 132,661,108

The IL13 gene is located on the long (q) arm of chromosome 5 at position 31.

The IL13 gene is located on the long (q) arm of chromosome 5 at position 31.

More precisely, the IL13 gene is located from base pair 132,658,172 to base pair 132,661,108 on chromosome 5.

See How do geneticists indicate the location of a gene? in the Handbook.

Where can I find additional information about IL13?

You may also be interested in these resources, which are designed for genetics professionals and researchers.

What other names do people use for the IL13 gene or gene products?

  • IL-13
  • P600

Where can I find general information about genes?

The Handbook provides basic information about genetics in clear language.

These links provide additional genetics resources that may be useful.

What glossary definitions help with understanding IL13?

cell ; chromosome ; class ; cytokine ; differentiation ; eosinophils ; gene ; inflammation ; inheritance ; macrophage ; Met ; MHC ; Pro ; susceptibility ; synthesis

You may find definitions for these and many other terms in the Genetics Home Reference Glossary.

See also Understanding Medical Terminology.

 

The resources on this site should not be used as a substitute for professional medical care or advice. Users seeking information about a personal genetic disease, syndrome, or condition should consult with a qualified healthcare professional. See How can I find a genetics professional in my area? in the Handbook.

 
Published: September 15, 2014