|A service of the U.S. National Library of Medicine®|
On this page:
Reviewed August 2013
What is the official name of the IKBKG gene?
The official name of this gene is “inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma.”
IKBKG is the gene's official symbol. The IKBKG gene is also known by other names, listed below.
Read more about gene names and symbols on the About page.
What is the normal function of the IKBKG gene?
The IKBKG gene provides instructions for producing one piece (subunit) of the IKK protein complex, which is a group of related proteins that regulates the activity of nuclear factor-kappa-B. Nuclear factor-kappa-B is a protein complex that binds to DNA and controls the activity of other genes. When it is turned off (inactive), nuclear factor-kappa-B is attached (bound) to the IKK complex. In response to certain signals, the IKK complex turns on (activates) nuclear factor-kappa-B and releases it.
The IKBKG protein plays a regulatory role in the IKK complex. Once the IKBKG protein is turned on (activated), it activates the other proteins in the complex, which in turn activates and releases nuclear factor-kappa-B. The activated factor then moves into the nucleus and binds to DNA. Nuclear factor-kappa-B regulates the activity of multiple genes, including genes that control the body's immune responses and inflammatory reactions. Nuclear factor-kappa-B also appears to play a role in the signaling pathway that is critical for the formation of ectodermal tissues including the skin, hair, teeth, and sweat glands. In addition, it protects the cell from certain signals that would otherwise cause it to self-destruct (undergo apoptosis).
Does the IKBKG gene share characteristics with other genes?
The IKBKG gene belongs to a family of genes called ZC2HC (zinc fingers, C2HC-type).
A gene family is a group of genes that share important characteristics. Classifying individual genes into families helps researchers describe how genes are related to each other. For more information, see What are gene families? in the Handbook.
How are changes in the IKBKG gene related to health conditions?
Where is the IKBKG gene located?
Cytogenetic Location: Xq28
Molecular Location on the X chromosome: base pairs 154,541,204 to 154,568,573
(Homo sapiens Annotation Release 107, GRCh38.p2) (
The IKBKG gene is located on the long (q) arm of the X chromosome at position 28.
More precisely, the IKBKG gene is located from base pair 154,541,204 to base pair 154,568,573 on the X chromosome.
See How do geneticists indicate the location of a gene? in the Handbook.
Where can I find additional information about IKBKG?
You and your healthcare professional may find the following resources about IKBKG helpful.
You may also be interested in these resources, which are designed for genetics professionals and researchers.
What other names do people use for the IKBKG gene or gene products?
See How are genetic conditions and genes named? in the Handbook.
Where can I find general information about genes?
The Handbook provides basic information about genetics in clear language.
These links provide additional genetics resources that may be useful.
What glossary definitions help with understanding IKBKG?
apoptosis ; bacteria ; B-cells ; cell ; deficiency ; DNA ; dysplasia ; ectoderm ; enhancer ; gene ; immune system ; immunodeficiency ; infection ; inheritance ; kinase ; lymphedema ; mutation ; mycobacteria ; mycobacterium ; nucleus ; pattern of inheritance ; protein ; rearrangement ; respiratory ; subunit ; susceptibility ; tuberculosis
You may find definitions for these and many other terms in the Genetics Home Reference Glossary.
See also Understanding Medical Terminology.
References (15 links)
The resources on this site should not be used as a substitute for professional medical care or advice. Users seeking information about a personal genetic disease, syndrome, or condition should consult with a qualified healthcare professional. See How can I find a genetics professional in my area? in the Handbook.