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Reviewed May 2007
What is the official name of the IKBKAP gene?
The official name of this gene is “inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase complex-associated protein.”
IKBKAP is the gene's official symbol. The IKBKAP gene is also known by other names, listed below.
Read more about gene names and symbols on the About page.
What is the normal function of the IKBKAP gene?
The IKBKAP gene provides instructions for making a protein called IKK complex-associated protein (IKAP). This protein is found in a variety of cells throughout the body, including brain cells. It is part of a six-protein complex called the elongator complex. The elongator complex plays a key role in transcription, the process that transfers information in genes to the cell machinery that makes proteins. Researchers believe that the elongator complex is important for the transcription of proteins that affect the cell's structural framework (the cytoskeleton) and cell movement (motility). The cytoskeleton and cell motility are essential for the growth and development of cells. For example, the cytoskeleton plays a critical role in the growth of nerve cells, particularly the specialized extensions called axons and dendrites that are required for the transmission of nerve impulses. Cell motility is crucial for the movement of nerve cells to their proper locations in the brain.
How are changes in the IKBKAP gene related to health conditions?
Where is the IKBKAP gene located?
Cytogenetic Location: 9q31
Molecular Location on chromosome 9: base pairs 108,867,520 to 108,934,328
The IKBKAP gene is located on the long (q) arm of chromosome 9 at position 31.
More precisely, the IKBKAP gene is located from base pair 108,867,520 to base pair 108,934,328 on chromosome 9.
See How do geneticists indicate the location of a gene? in the Handbook.
Where can I find additional information about IKBKAP?
You and your healthcare professional may find the following resources about IKBKAP helpful.
You may also be interested in these resources, which are designed for genetics professionals and researchers.
What other names do people use for the IKBKAP gene or gene products?
See How are genetic conditions and genes named? in the Handbook.
Where can I find general information about genes?
The Handbook provides basic information about genetics in clear language.
These links provide additional genetics resources that may be useful.
What glossary definitions help with understanding IKBKAP?
You may find definitions for these and many other terms in the Genetics Home Reference Glossary.
See also Understanding Medical Terminology.
References (9 links)
The resources on this site should not be used as a substitute for professional medical care or advice. Users seeking information about a personal genetic disease, syndrome, or condition should consult with a qualified healthcare professional. See How can I find a genetics professional in my area? in the Handbook.