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Reviewed May 2015
What is the official name of the IFT80 gene?
The official name of this gene is “intraflagellar transport 80.”
IFT80 is the gene's official symbol. The IFT80 gene is also known by other names, listed below.
Read more about gene names and symbols on the About page.
What is the normal function of the IFT80 gene?
The IFT80 gene provides instructions for making a protein that is part of a group (complex) called IFT complex B. This complex is found in cell structures known as cilia. Cilia are microscopic, finger-like projections that stick out from the surface of cells. IFT complex B is involved in a process called intraflagellar transport (IFT), by which materials are carried within cilia. Specifically, this complex helps transport materials from the base of cilia to the tip.
IFT is essential for the assembly and maintenance of cilia. These cell structures play central roles in many different chemical signaling pathways, including a series of reactions called the Sonic Hedgehog pathway. These pathways are important for the growth and division (proliferation) and maturation (differentiation) of cells. In particular, Sonic Hedgehog appears to be essential for the proliferation and differentiation of cells that ultimately give rise to cartilage and bone.
Does the IFT80 gene share characteristics with other genes?
A gene family is a group of genes that share important characteristics. Classifying individual genes into families helps researchers describe how genes are related to each other. For more information, see What are gene families? in the Handbook.
How are changes in the IFT80 gene related to health conditions?
Where is the IFT80 gene located?
Cytogenetic Location: 3q25.33
Molecular Location on chromosome 3: base pairs 160,256,985 to 160,399,531
The IFT80 gene is located on the long (q) arm of chromosome 3 at position 25.33.
More precisely, the IFT80 gene is located from base pair 160,256,985 to base pair 160,399,531 on chromosome 3.
See How do geneticists indicate the location of a gene? in the Handbook.
Where can I find additional information about IFT80?
You and your healthcare professional may find the following resources about IFT80 helpful.
You may also be interested in these resources, which are designed for genetics professionals and researchers.
What other names do people use for the IFT80 gene or gene products?
See How are genetic conditions and genes named? in the Handbook.
Where can I find general information about genes?
The Handbook provides basic information about genetics in clear language.
These links provide additional genetics resources that may be useful.
What glossary definitions help with understanding IFT80?
You may find definitions for these and many other terms in the Genetics Home Reference Glossary.
See also Understanding Medical Terminology.
References (4 links)
The resources on this site should not be used as a substitute for professional medical care or advice. Users seeking information about a personal genetic disease, syndrome, or condition should consult with a qualified healthcare professional. See How can I find a genetics professional in my area? in the Handbook.