|A service of the U.S. National Library of Medicine®|
On this page:
Reviewed December 2008
What is the official name of the IDS gene?
The official name of this gene is “iduronate 2-sulfatase.”
IDS is the gene's official symbol. The IDS gene is also known by other names, listed below.
Read more about gene names and symbols on the About page.
What is the normal function of the IDS gene?
The IDS gene provides instructions for producing an enzyme called iduronate 2-sulfatase (I2S), which is essential for the breakdown of large sugar molecules called glycosaminoglycans (GAGs). Specifically, I2S removes a chemical group known as a sulfate from a molecule called sulfated alpha-L-iduronic acid, which is present in two GAGs called heparan sulfate and dermatan sulfate. I2S is located in lysosomes, compartments within cells that digest and recycle different types of molecules.
How are changes in the IDS gene related to health conditions?
Where is the IDS gene located?
Cytogenetic Location: Xq28
Molecular Location on the X chromosome: base pairs 149,478,764 to 149,505,354
(Homo sapiens Annotation Release 107, GRCh38.p2) (
The IDS gene is located on the long (q) arm of the X chromosome at position 28.
More precisely, the IDS gene is located from base pair 149,478,764 to base pair 149,505,354 on the X chromosome.
See How do geneticists indicate the location of a gene? in the Handbook.
Where can I find additional information about IDS?
You and your healthcare professional may find the following resources about IDS helpful.
You may also be interested in these resources, which are designed for genetics professionals and researchers.
What other names do people use for the IDS gene or gene products?
See How are genetic conditions and genes named? in the Handbook.
Where can I find general information about genes?
The Handbook provides basic information about genetics in clear language.
These links provide additional genetics resources that may be useful.
What glossary definitions help with understanding IDS?
You may find definitions for these and many other terms in the Genetics Home Reference Glossary.
See also Understanding Medical Terminology.
References (6 links)
The resources on this site should not be used as a substitute for professional medical care or advice. Users seeking information about a personal genetic disease, syndrome, or condition should consult with a qualified healthcare professional. See How can I find a genetics professional in my area? in the Handbook.