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Reviewed August 2013
What is the official name of the IDH2 gene?
The official name of this gene is “isocitrate dehydrogenase 2 (NADP+), mitochondrial.”
IDH2 is the gene's official symbol. The IDH2 gene is also known by other names, listed below.
Read more about gene names and symbols on the About page.
What is the normal function of the IDH2 gene?
The IDH2 gene provides instructions for making an enzyme called isocitrate dehydrogenase 2. This enzyme is found in mitochondria, which are the energy-producing centers within cells. Within mitochondria, the enzyme participates in reactions that produce energy for cell activities. Specifically, isocitrate dehydrogenase 2 normally converts a compound called isocitrate to another compound called 2-ketoglutarate. A series of additional enzymes further process 2-ketoglutarate to produce energy.
How are changes in the IDH2 gene related to health conditions?
Genetics Home Reference provides information about primary myelofibrosis, which is also associated with changes in the IDH2 gene.
Where is the IDH2 gene located?
Cytogenetic Location: 15q26.1
Molecular Location on chromosome 15: base pairs 90,626,282 to 90,645,729
The IDH2 gene is located on the long (q) arm of chromosome 15 at position 26.1.
More precisely, the IDH2 gene is located from base pair 90,626,282 to base pair 90,645,729 on chromosome 15.
See How do geneticists indicate the location of a gene? in the Handbook.
Where can I find additional information about IDH2?
You and your healthcare professional may find the following resources about IDH2 helpful.
You may also be interested in these resources, which are designed for genetics professionals and researchers.
What other names do people use for the IDH2 gene or gene products?
See How are genetic conditions and genes named? in the Handbook.
Where can I find general information about genes?
The Handbook provides basic information about genetics in clear language.
These links provide additional genetics resources that may be useful.
What glossary definitions help with understanding IDH2?
You may find definitions for these and many other terms in the Genetics Home Reference Glossary.
See also Understanding Medical Terminology.
References (8 links)
The resources on this site should not be used as a substitute for professional medical care or advice. Users seeking information about a personal genetic disease, syndrome, or condition should consult with a qualified healthcare professional. See How can I find a genetics professional in my area? in the Handbook.