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Reviewed January 2010
What is the official name of the HSPB8 gene?
The official name of this gene is “heat shock protein family B (small) member 8.”
HSPB8 is the gene's official symbol. The HSPB8 gene is also known by other names, listed below.
Read more about gene names and symbols on the About page.
What is the normal function of the HSPB8 gene?
The HSPB8 gene provides instructions for making a protein called heat shock protein beta-8 (also called heat shock protein 22). This protein is a member of the heat shock protein family, which helps protect cells under adverse conditions such as infection, inflammation, exposure to toxins, elevated temperature, injury, and disease. Heat shock proteins block signals that lead to programmed cell death. In addition, they appear to be involved in activities such as cell movement (motility), stabilizing the cell's structural framework (the cytoskeleton), folding and stabilizing newly produced proteins, and repairing damaged proteins. Heat shock proteins also appear to play a role in the tensing of muscle fibers (muscle contraction).
Heat shock protein beta-8 is found in cells throughout the body and is particularly abundant in nerve cells. While its function is not well understood, it seems to interact with a related protein called heat shock protein beta-1, produced from the HSPB1 gene. In nerve cells, heat shock protein beta-1 helps to organize a network of molecular threads called neurofilaments that maintain the diameter of specialized extensions called axons. Maintaining proper axon diameter is essential for the efficient transmission of nerve impulses. The specific role that heat shock protein beta-8 plays in axons is unclear.
How are changes in the HSPB8 gene related to health conditions?
Where is the HSPB8 gene located?
Cytogenetic Location: 12q24.23
Molecular Location on chromosome 12: base pairs 119,178,790 to 119,194,746
(Homo sapiens Annotation Release 107, GRCh38.p2) (
The HSPB8 gene is located on the long (q) arm of chromosome 12 at position 24.23.
More precisely, the HSPB8 gene is located from base pair 119,178,790 to base pair 119,194,746 on chromosome 12.
See How do geneticists indicate the location of a gene? in the Handbook.
Where can I find additional information about HSPB8?
You and your healthcare professional may find the following resources about HSPB8 helpful.
You may also be interested in these resources, which are designed for genetics professionals and researchers.
What other names do people use for the HSPB8 gene or gene products?
See How are genetic conditions and genes named? in the Handbook.
Where can I find general information about genes?
The Handbook provides basic information about genetics in clear language.
These links provide additional genetics resources that may be useful.
What glossary definitions help with understanding HSPB8?
amino acid ; asparagine ; axons ; cell ; contraction ; cytoskeleton ; diameter ; distal ; gene ; glutamic acid ; hereditary ; infection ; inflammation ; injury ; kinase ; lysine ; motor ; mutation ; neuropathy ; peripheral ; peripheral nerves ; protein ; sensory cells ; shock ; stress
You may find definitions for these and many other terms in the Genetics Home Reference Glossary.
See also Understanding Medical Terminology.
References (13 links)
The resources on this site should not be used as a substitute for professional medical care or advice. Users seeking information about a personal genetic disease, syndrome, or condition should consult with a qualified healthcare professional. See How can I find a genetics professional in my area? in the Handbook.