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Reviewed January 2010
What is the official name of the HSPB1 gene?
The official name of this gene is “heat shock 27kDa protein 1.”
HSPB1 is the gene's official symbol. The HSPB1 gene is also known by other names, listed below.
Read more about gene names and symbols on the About page.
What is the normal function of the HSPB1 gene?
The HSPB1 gene provides instructions for making a protein called heat shock protein beta-1 (also called heat shock protein 27). This protein is a member of the heat shock protein family, which helps protect cells under adverse conditions such as infection, inflammation, exposure to toxins, elevated temperature, injury, and disease. Heat shock proteins block signals that lead to programmed cell death. In addition, they appear to be involved in activities such as cell movement (motility), stabilizing the cell's structural framework (the cytoskeleton), folding and stabilizing newly produced proteins, and repairing damaged proteins. Heat shock proteins also appear to play a role in the tensing of muscle fibers (muscle contraction).
Heat shock protein beta-1 is found in cells throughout the body and is particularly abundant in nerve and muscle cells. In nerve cells, this protein helps to organize a network of molecular threads called neurofilaments that maintain the diameter of specialized extensions called axons. Maintaining proper axon diameter is essential for the efficient transmission of nerve impulses. Although it is thought to play a role in muscle contraction, the specific function of heat shock protein beta-1 in muscle cells is unclear.
How are changes in the HSPB1 gene related to health conditions?
Where is the HSPB1 gene located?
Cytogenetic Location: 7q11.23
Molecular Location on chromosome 7: base pairs 76,302,557 to 76,304,296
The HSPB1 gene is located on the long (q) arm of chromosome 7 at position 11.23.
More precisely, the HSPB1 gene is located from base pair 76,302,557 to base pair 76,304,296 on chromosome 7.
See How do geneticists indicate the location of a gene? in the Handbook.
Where can I find additional information about HSPB1?
You and your healthcare professional may find the following resources about HSPB1 helpful.
You may also be interested in these resources, which are designed for genetics professionals and researchers.
What other names do people use for the HSPB1 gene or gene products?
See How are genetic conditions and genes named? in the Handbook.
Where can I find general information about genes?
The Handbook provides basic information about genetics in clear language.
These links provide additional genetics resources that may be useful.
What glossary definitions help with understanding HSPB1?
acids ; aggregate ; amino acid ; arginine ; axons ; cell ; contraction ; cytoskeleton ; diameter ; distal ; gene ; hereditary ; infection ; inflammation ; injury ; motor ; muscle cells ; mutation ; neuropathy ; peripheral ; peripheral nerves ; phenylalanine ; protein ; sensory cells ; serine ; shock ; stress ; tryptophan
You may find definitions for these and many other terms in the Genetics Home Reference Glossary.
See also Understanding Medical Terminology.
References (17 links)
The resources on this site should not be used as a substitute for professional medical care or advice. Users seeking information about a personal genetic disease, syndrome, or condition should consult with a qualified healthcare professional. See How can I find a genetics professional in my area? in the Handbook.