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Reviewed October 2009
What is the official name of the HCCS gene?
The official name of this gene is “holocytochrome c synthase.”
HCCS is the gene's official symbol. The HCCS gene is also known by other names, listed below.
Read more about gene names and symbols on the About page.
What is the normal function of the HCCS gene?
The HCCS gene carries instructions for producing an enzyme called holocytochrome c-type synthase. This enzyme is active in many tissues of the body and is found in the mitochondria, the energy-producing centers within cells.
Within the mitochondria, the holocytochrome c-type synthase enzyme helps produce a molecule called cytochrome c. Specifically, holocytochrome c-type synthase is involved in a reaction that adds an iron-containing molecule called heme to make mature cytochrome c, also called holocytochrome c, from a precursor form called apocytochrome c.
Cytochrome c is involved in a process called oxidative phosphorylation, by which mitochondria generate adenosine triphosphate (ATP), the cell's main energy source. It also plays a role in the self-destruction of cells (apoptosis).
How are changes in the HCCS gene related to health conditions?
Where is the HCCS gene located?
Cytogenetic Location: Xp22.3
Molecular Location on the X chromosome: base pairs 11,111,286 to 11,123,086
The HCCS gene is located on the short (p) arm of the X chromosome at position 22.3.
More precisely, the HCCS gene is located from base pair 11,111,286 to base pair 11,123,086 on the X chromosome.
See How do geneticists indicate the location of a gene? in the Handbook.
Where can I find additional information about HCCS?
You and your healthcare professional may find the following resources about HCCS helpful.
You may also be interested in these resources, which are designed for genetics professionals and researchers.
What other names do people use for the HCCS gene or gene products?
See How are genetic conditions and genes named? in the Handbook.
Where can I find general information about genes?
The Handbook provides basic information about genetics in clear language.
These links provide additional genetics resources that may be useful.
What glossary definitions help with understanding HCCS?
adenosine triphosphate ; apoptosis ; ATP ; cell ; deletion ; enzyme ; gene ; heme ; inflammation ; iron ; mitochondria ; molecule ; necrosis ; oxidative phosphorylation ; phosphorylation ; precursor ; syndrome
You may find definitions for these and many other terms in the Genetics Home Reference Glossary.
See also Understanding Medical Terminology.
References (5 links)
The resources on this site should not be used as a substitute for professional medical care or advice. Users seeking information about a personal genetic disease, syndrome, or condition should consult with a qualified healthcare professional. See How can I find a genetics professional in my area? in the Handbook.