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Reviewed December 2006
What is the official name of the GSS gene?
The official name of this gene is “glutathione synthetase.”
GSS is the gene's official symbol. The GSS gene is also known by other names, listed below.
Read more about gene names and symbols on the About page.
What is the normal function of the GSS gene?
The GSS gene provides instructions for making an enzyme called glutathione synthetase. Glutathione synthetase participates in a process called the gamma-glutamyl cycle. The gamma-glutamyl cycle is a sequence of chemical reactions that takes place in most of the body's cells. These reactions are necessary for the production of glutathione, a small molecule made of three protein building blocks (amino acids). Glutathione protects cells from damage caused by unstable oxygen-containing molecules, which are byproducts of energy production. Glutathione is called an antioxidant because of its role in protecting cells from the damaging effects of these unstable molecules. Glutathione also helps process medications and cancer-causing compounds (carcinogens), and helps build DNA, proteins, and other important cellular components.
How are changes in the GSS gene related to health conditions?
Where is the GSS gene located?
Cytogenetic Location: 20q11.2
Molecular Location on chromosome 20: base pairs 34,928,432 to 34,955,797
The GSS gene is located on the long (q) arm of chromosome 20 at position 11.2.
More precisely, the GSS gene is located from base pair 34,928,432 to base pair 34,955,797 on chromosome 20.
See How do geneticists indicate the location of a gene? in the Handbook.
Where can I find additional information about GSS?
You and your healthcare professional may find the following resources about GSS helpful.
You may also be interested in these resources, which are designed for genetics professionals and researchers.
What other names do people use for the GSS gene or gene products?
See How are genetic conditions and genes named? in the Handbook.
Where can I find general information about genes?
The Handbook provides basic information about genetics in clear language.
These links provide additional genetics resources that may be useful.
What glossary definitions help with understanding GSS?
You may find definitions for these and many other terms in the Genetics Home Reference Glossary.
See also Understanding Medical Terminology.
References (6 links)
The resources on this site should not be used as a substitute for professional medical care or advice. Users seeking information about a personal genetic disease, syndrome, or condition should consult with a qualified healthcare professional. See How can I find a genetics professional in my area? in the Handbook.