|A service of the U.S. National Library of Medicine®|
On this page:
Reviewed December 2013
What is the official name of the GPI gene?
The official name of this gene is “glucose-6-phosphate isomerase.”
GPI is the gene's official symbol. The GPI gene is also known by other names, listed below.
Read more about gene names and symbols on the About page.
What is the normal function of the GPI gene?
The GPI gene provides instructions for making an enzyme called glucose phosphate isomerase (GPI). This enzyme has two distinct functions based on its structure. When two GPI molecules form a complex (a homodimer), the enzyme plays a role in a critical energy-producing process known as glycolysis, also called the glycolytic pathway. During glycolysis, the simple sugar glucose is broken down to produce energy. Specifically, GPI is involved in the second step of the glycolytic pathway; in this step, a molecule called glucose-6-phosphate is converted to another molecule called fructose-6-phosphate.
When GPI remains a single molecule (a monomer) it is involved in the development and maintenance of nerve cells (neurons). In this context, it is often known as neuroleukin (NLK).
The monomer is also produced by cancer cells and functions to promote spreading (metastasis) of the cancer; in this context it is called autocrine motility factor (AMF).
How are changes in the GPI gene related to health conditions?
Where is the GPI gene located?
Cytogenetic Location: 19q13.1
Molecular Location on chromosome 19: base pairs 34,359,592 to 34,402,413
(Homo sapiens Annotation Release 107, GRCh38.p2) (
The GPI gene is located on the long (q) arm of chromosome 19 at position 13.1.
More precisely, the GPI gene is located from base pair 34,359,592 to base pair 34,402,413 on chromosome 19.
See How do geneticists indicate the location of a gene? in the Handbook.
Where can I find additional information about GPI?
You and your healthcare professional may find the following resources about GPI helpful.
You may also be interested in these resources, which are designed for genetics professionals and researchers.
What other names do people use for the GPI gene or gene products?
See How are genetic conditions and genes named? in the Handbook.
Where can I find general information about genes?
The Handbook provides basic information about genetics in clear language.
These links provide additional genetics resources that may be useful.
What glossary definitions help with understanding GPI?
acids ; anemia ; ataxia ; autocrine ; cancer ; chronic ; deficiency ; disability ; enzyme ; fructose ; gene ; glucose ; hemolysis ; hemolytic anemia ; inherited ; metastasis ; molecule ; monomer ; neurological ; oxygen ; phosphate ; protein ; red cells ; simple sugar ; sperm
You may find definitions for these and many other terms in the Genetics Home Reference Glossary.
See also Understanding Medical Terminology.
References (11 links)
The resources on this site should not be used as a substitute for professional medical care or advice. Users seeking information about a personal genetic disease, syndrome, or condition should consult with a qualified healthcare professional. See How can I find a genetics professional in my area? in the Handbook.