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Reviewed December 2008
What is the official name of the GNE gene?
The official name of this gene is “glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase.”
GNE is the gene's official symbol. The GNE gene is also known by other names, listed below.
Read more about gene names and symbols on the About page.
What is the normal function of the GNE gene?
The GNE gene provides instructions for making an enzyme that is found in cells and tissues throughout the body. This enzyme plays a key role in a chemical pathway that produces sialic acid, which is a simple sugar that attaches to the ends of more complex molecules on the surface of cells. By modifying these molecules, sialic acid influences a wide variety of cellular functions including cell movement (migration), attaching cells to one another (adhesion), signaling between cells, and inflammation.
The enzyme produced from the GNE gene is responsible for two steps in the formation of sialic acid. It first converts a molecule known as UDP-GlcNAc to a similar molecule called ManNAc. In the next step, the enzyme transfers a cluster of oxygen and phosphorus atoms (a phosphate group) to ManNAc to create ManNAc-6-phosphate. Other enzymes then convert ManNAc-6-phosphate to sialic acid.
How are changes in the GNE gene related to health conditions?
Where is the GNE gene located?
Cytogenetic Location: 9p13.3
Molecular Location on chromosome 9: base pairs 36,214,441 to 36,277,056
(Homo sapiens Annotation Release 107, GRCh38.p2) (
The GNE gene is located on the short (p) arm of chromosome 9 at position 13.3.
More precisely, the GNE gene is located from base pair 36,214,441 to base pair 36,277,056 on chromosome 9.
See How do geneticists indicate the location of a gene? in the Handbook.
Where can I find additional information about GNE?
You and your healthcare professional may find the following resources about GNE helpful.
You may also be interested in these resources, which are designed for genetics professionals and researchers.
What other names do people use for the GNE gene or gene products?
See How are genetic conditions and genes named? in the Handbook.
Where can I find general information about genes?
The Handbook provides basic information about genetics in clear language.
These links provide additional genetics resources that may be useful.
What glossary definitions help with understanding GNE?
acids ; amino acid ; cell ; domain ; enzyme ; gene ; glycolipids ; glycoproteins ; inclusion body ; inflammation ; kinase ; leucine ; methionine ; molecule ; mutation ; oxygen ; phosphate ; phosphorus ; population ; protein ; sialic acid ; simple sugar ; threonine ; valine
You may find definitions for these and many other terms in the Genetics Home Reference Glossary.
See also Understanding Medical Terminology.
References (15 links)
The resources on this site should not be used as a substitute for professional medical care or advice. Users seeking information about a personal genetic disease, syndrome, or condition should consult with a qualified healthcare professional. See How can I find a genetics professional in my area? in the Handbook.