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Reviewed March 2006
What is the official name of the GLI3 gene?
The official name of this gene is “GLI family zinc finger 3.”
GLI3 is the gene's official symbol. The GLI3 gene is also known by other names, listed below.
Read more about gene names and symbols on the About page.
What is the normal function of the GLI3 gene?
The GLI3 gene belongs to a family of genes that are involved in the normal shaping (patterning) of many tissues and organs during embryonic development. To carry out this role, proteins made by genes in the GLI family attach to specific regions of DNA and help control whether particular genes are turned on or off (gene expression). GLI proteins are called transcription factors on the basis of this action.
Proteins in the GLI family function in the same molecular pathway as a protein called Sonic Hedgehog. This pathway is essential for early development. It plays a role in cell growth, cell specialization, and the patterning of structures such as the brain and limbs. Depending on signals from Sonic Hedgehog, the GLI3 protein can either turn on (activate) or turn off (repress) other genes. Researchers are working to identify the genes targeted by the GLI3 protein during development.
How are changes in the GLI3 gene related to health conditions?
Where is the GLI3 gene located?
Cytogenetic Location: 7p13
Molecular Location on chromosome 7: base pairs 41,960,949 to 42,264,112
(Homo sapiens Annotation Release 107, GRCh38.p2) (
The GLI3 gene is located on the short (p) arm of chromosome 7 at position 13.
More precisely, the GLI3 gene is located from base pair 41,960,949 to base pair 42,264,112 on chromosome 7.
See How do geneticists indicate the location of a gene? in the Handbook.
Where can I find additional information about GLI3?
You and your healthcare professional may find the following resources about GLI3 helpful.
You may also be interested in these resources, which are designed for genetics professionals and researchers.
What other names do people use for the GLI3 gene or gene products?
See How are genetic conditions and genes named? in the Handbook.
Where can I find general information about genes?
The Handbook provides basic information about genetics in clear language.
These links provide additional genetics resources that may be useful.
What glossary definitions help with understanding GLI3?
You may find definitions for these and many other terms in the Genetics Home Reference Glossary.
See also Understanding Medical Terminology.
References (15 links)
The resources on this site should not be used as a substitute for professional medical care or advice. Users seeking information about a personal genetic disease, syndrome, or condition should consult with a qualified healthcare professional. See How can I find a genetics professional in my area? in the Handbook.