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Reviewed February 2012
What is the official name of the GH1 gene?
The official name of this gene is “growth hormone 1.”
GH1 is the gene's official symbol. The GH1 gene is also known by other names, listed below.
Read more about gene names and symbols on the About page.
What is the normal function of the GH1 gene?
The GH1 gene provides instructions for making the growth hormone protein. Growth hormone is produced in the growth-stimulating somatotropic cells of the pituitary gland, which is located at the base of the brain. Growth hormone is necessary for the normal growth of the body's bones and tissues. The production of growth hormone is triggered when two other hormones are turned on (activated): ghrelin, which is produced in the stomach; and growth hormone releasing hormone, which is produced in a part of the brain called the hypothalamus. Ghrelin and growth hormone releasing hormone also stimulate the release of growth hormone from the pituitary gland. The release of growth hormone into the body peaks during puberty and reaches a low point at about age 55.
Cells in the liver respond to growth hormone and trigger the production of a protein called insulin-like growth factor-I (IGF-I). This protein stimulates cell growth and cell maturation (differentiation) in many different tissues, including bone. The production of IGF-I by the actions of growth hormone is a major contributor to the promotion of growth.
Growth hormone also plays a role in many chemical reactions (metabolic processes) in the body. By acting on specific tissues, growth hormone is involved in protein production and the breakdown (metabolism) of fats and carbohydrates.
Does the GH1 gene share characteristics with other genes?
The GH1 gene belongs to a family of genes called endogenous ligands (endogenous ligands).
A gene family is a group of genes that share important characteristics. Classifying individual genes into families helps researchers describe how genes are related to each other. For more information, see What are gene families? in the Handbook.
How are changes in the GH1 gene related to health conditions?
Where is the GH1 gene located?
Cytogenetic Location: 17q24.2
Molecular Location on chromosome 17: base pairs 63,917,192 to 63,918,851
The GH1 gene is located on the long (q) arm of chromosome 17 at position 24.2.
More precisely, the GH1 gene is located from base pair 63,917,192 to base pair 63,918,851 on chromosome 17.
See How do geneticists indicate the location of a gene? in the Handbook.
Where can I find additional information about GH1?
You and your healthcare professional may find the following resources about GH1 helpful.
You may also be interested in these resources, which are designed for genetics professionals and researchers.
What other names do people use for the GH1 gene or gene products?
See How are genetic conditions and genes named? in the Handbook.
Where can I find general information about genes?
The Handbook provides basic information about genetics in clear language.
These links provide additional genetics resources that may be useful.
What glossary definitions help with understanding GH1?
breakdown ; cell ; deficiency ; deletion ; differentiation ; gene ; GH ; growth factor ; growth hormone ; hormone ; hypothalamus ; insulin ; intron ; metabolic processes ; metabolism ; pituitary gland ; pituitary growth hormone ; protein ; puberty ; short stature ; somatotropin ; stature ; stomach
You may find definitions for these and many other terms in the Genetics Home Reference Glossary.
See also Understanding Medical Terminology.
References (7 links)
The resources on this site should not be used as a substitute for professional medical care or advice. Users seeking information about a personal genetic disease, syndrome, or condition should consult with a qualified healthcare professional. See How can I find a genetics professional in my area? in the Handbook.