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Reviewed October 2007
What is the official name of the GAN gene?
The official name of this gene is “gigaxonin.”
GAN is the gene's official symbol. The GAN gene is also known by other names, listed below.
Read more about gene names and symbols on the About page.
What is the normal function of the GAN gene?
The GAN gene provides instructions for making a protein called gigaxonin. Gigaxonin is involved in a cellular function that destroys and gets rid of excess or damaged proteins using a mechanism called the ubiquitin-proteasome system. The ubiquitin-proteasome system is a multi-step process that begins with the activation of a protein called ubiquitin. With the assistance of other proteins called ubiquitin-conjugating enzymes and ubiquitin ligases, the ubiquitin attaches to a targeted protein. When a chain of ubiquitin proteins is attached to the targeted protein, the protein is recognized and destroyed by a complex of enzymes called a proteasome.
Researchers believe that gigaxonin belongs to a group of ubiquitin ligases called the BTB/kelch superfamily. These ubiquitin ligases help ubiquitin target specific proteins for destruction. Gigaxonin targets proteins that must be broken down in order for the cytoskeleton, the framework that gives structure to cells, to develop properly.
How are changes in the GAN gene related to health conditions?
Where is the GAN gene located?
Cytogenetic Location: 16q24.1
Molecular Location on chromosome 16: base pairs 81,314,966 to 81,380,198
(Homo sapiens Annotation Release 107, GRCh38.p2) (
The GAN gene is located on the long (q) arm of chromosome 16 at position 24.1.
More precisely, the GAN gene is located from base pair 81,314,966 to base pair 81,380,198 on chromosome 16.
See How do geneticists indicate the location of a gene? in the Handbook.
Where can I find additional information about GAN?
You and your healthcare professional may find the following resources about GAN helpful.
You may also be interested in these resources, which are designed for genetics professionals and researchers.
What other names do people use for the GAN gene or gene products?
See How are genetic conditions and genes named? in the Handbook.
Where can I find general information about genes?
The Handbook provides basic information about genetics in clear language.
These links provide additional genetics resources that may be useful.
What glossary definitions help with understanding GAN?
acids ; axons ; cell ; central nervous system ; cytoskeleton ; deficiency ; distended ; gene ; nerve cell ; nervous system ; neuropathy ; peripheral ; peripheral nerves ; proteasome ; protein ; ubiquitin
You may find definitions for these and many other terms in the Genetics Home Reference Glossary.
See also Understanding Medical Terminology.
References (13 links)
The resources on this site should not be used as a substitute for professional medical care or advice. Users seeking information about a personal genetic disease, syndrome, or condition should consult with a qualified healthcare professional. See How can I find a genetics professional in my area? in the Handbook.