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Reviewed July 2010
What is the official name of the GALNS gene?
The official name of this gene is “galactosamine (N-acetyl)-6-sulfatase.”
GALNS is the gene's official symbol. The GALNS gene is also known by other names, listed below.
Read more about gene names and symbols on the About page.
What is the normal function of the GALNS gene?
The GALNS gene provides instructions for producing an enzyme called N-acetylgalactosamine 6-sulfatase. This enzyme is located in lysosomes, which are compartments within cells that break down and recycle different types of molecules. N-acetylgalactosamine 6-sulfatase is involved in the breakdown of large sugar molecules called glycosaminoglycans (GAGs) or mucopolysaccharides. Specifically, this enzyme removes a chemical group known as a sulfate from a GAG called keratan sulfate. Keratan sulfate is particularly abundant in cartilage and the clear covering of the eye (cornea).
How are changes in the GALNS gene related to health conditions?
Where is the GALNS gene located?
Cytogenetic Location: 16q24.3
Molecular Location on chromosome 16: base pairs 88,813,734 to 88,856,966
The GALNS gene is located on the long (q) arm of chromosome 16 at position 24.3.
More precisely, the GALNS gene is located from base pair 88,813,734 to base pair 88,856,966 on chromosome 16.
See How do geneticists indicate the location of a gene? in the Handbook.
Where can I find additional information about GALNS?
You and your healthcare professional may find the following resources about GALNS helpful.
You may also be interested in these resources, which are designed for genetics professionals and researchers.
What other names do people use for the GALNS gene or gene products?
See How are genetic conditions and genes named? in the Handbook.
Where can I find general information about genes?
The Handbook provides basic information about genetics in clear language.
These links provide additional genetics resources that may be useful.
What glossary definitions help with understanding GALNS?
You may find definitions for these and many other terms in the Genetics Home Reference Glossary.
See also Understanding Medical Terminology.
References (5 links)
The resources on this site should not be used as a substitute for professional medical care or advice. Users seeking information about a personal genetic disease, syndrome, or condition should consult with a qualified healthcare professional. See How can I find a genetics professional in my area? in the Handbook.