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Reviewed June 2014
What is the official name of the FREM2 gene?
The official name of this gene is “FRAS1 related extracellular matrix protein 2.”
FREM2 is the gene's official symbol. The FREM2 gene is also known by other names, listed below.
Read more about gene names and symbols on the About page.
What is the normal function of the FREM2 gene?
The FREM2 gene provides instructions for making a protein that is part of a group of proteins called the FRAS/FREM complex; in addition to being part of the complex, FREM2 regulates the complex's formation. The FRAS/FREM complex is found in basement membranes, which are thin, sheet-like structures that separate and support cells in many tissues. The complex is particularly important during development before birth. One of its roles is to anchor the top layer of skin by connecting the basement membrane of the top layer to the layer of skin below. The FRAS/FREM complex is also involved in the proper development of certain other organs and tissues, including the kidneys, although the mechanism is unclear.
How are changes in the FREM2 gene related to health conditions?
Where is the FREM2 gene located?
Cytogenetic Location: 13q13.3
Molecular Location on chromosome 13: base pairs 38,687,036 to 38,887,131
(Homo sapiens Annotation Release 107, GRCh38.p2) (
The FREM2 gene is located on the long (q) arm of chromosome 13 at position 13.3.
More precisely, the FREM2 gene is located from base pair 38,687,036 to base pair 38,887,131 on chromosome 13.
See How do geneticists indicate the location of a gene? in the Handbook.
Where can I find additional information about FREM2?
You and your healthcare professional may find the following resources about FREM2 helpful.
You may also be interested in these resources, which are designed for genetics professionals and researchers.
What other names do people use for the FREM2 gene or gene products?
See How are genetic conditions and genes named? in the Handbook.
Where can I find general information about genes?
The Handbook provides basic information about genetics in clear language.
These links provide additional genetics resources that may be useful.
What glossary definitions help with understanding FREM2?
You may find definitions for these and many other terms in the Genetics Home Reference Glossary.
See also Understanding Medical Terminology.
References (8 links)
The resources on this site should not be used as a substitute for professional medical care or advice. Users seeking information about a personal genetic disease, syndrome, or condition should consult with a qualified healthcare professional. See How can I find a genetics professional in my area? in the Handbook.